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Deformation stimulates bone – feasibility of an innovative surgical approach for in-vivo measurements of bone deformation

Ganse, Bergita and Yang, Pengfei and Brüggemann, Gert-Peter and Koy, Timmo and Rittweger, Joern and Müller, Lars Peter (2013) Deformation stimulates bone – feasibility of an innovative surgical approach for in-vivo measurements of bone deformation. 19th IAA Humans in Space Symposium 2013, 7.-12. July 2013, Köln, Germany.

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Abstract

Introduction: Bone deformation stimulates bone and is crucial for astronauts during space flight. Knowledge on bone deformation during activities could help improve astronaut training and osteoporosis treatment. A new method for in vivo bone deformation measurements was developed by the authors, offering technical advantages over previous approaches. Using motion capturing, it computes deformation from the relative displacement between reflective markers attached to the bone via screws. This technique is less invasive than strain gauges attached to the bone surface. However, feasibility of the approach had been almost unanimously rejected by colleagues and experts in the up-run for this study. Their main concerns were pain and infection. Materials and Methods: Aim of the study was to evaluate feasibility regarding surgical technique, pain, risk of infection, bleeding and wound healing in five healthy subjects between 26 and 50 years of age (mean 37.2 years +/- 7.8). Three titanium screws were inserted 3 mm into the cortical bone of the tibia in local anesthesia fig. 1). Screws were in place for 6 to 8 hours, during which a variety of exercises were performed including running, jumping, stairs and squats. A pain questionnaire was used to assess pain levels during experiments. The visual analog scale ranging from 0 to 10 and open questions were employed. Bone scans were taken to locate and evaluate screw holes. Opening of the medulla would aggravate outcomes in case of infection. Results: Feasibility was good and screws remained in place throughout experiments. The average pain level throughout the experiment day was 0. Screw implantation and explantation can be done in local anesthesia, and a large number of exercises can be performed with only a minimum of pain medication. PQCT-images showed the bone medulla was not opened in any case. In the first subject, bleeding caused interruptions. This problem was controlled through size-reduction of skin incisions, application of ‘steri strips’ and extensive cauterization. Wound healing was without complications in all subjects. Discussion: The new optical method is feasible from a surgical point of view with astoundingly low levels of pain and discomfort. The threat of infection was minimized. Bleeding was efficiently reduced and wound healing was without complications. The new method is feasible from a surgical point of view and opens a variety of options for new clinical and scientific applications.

Item URL in elib:https://elib.dlr.de/85032/
Document Type:Conference or Workshop Item (Poster)
Title:Deformation stimulates bone – feasibility of an innovative surgical approach for in-vivo measurements of bone deformation
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Ganse, Bergitabergita.ganse (at) dlr.deUNSPECIFIED
Yang, PengfeiPengfei.Yang (at) dlr.deUNSPECIFIED
Brüggemann, Gert-Peterbrueggemann (at) dshs-koeln.deUNSPECIFIED
Koy, Timmotimmo.koy (at) uk-koeln.deUNSPECIFIED
Rittweger, Joernjoern.rittweger (at) dlr.deUNSPECIFIED
Müller, Lars Peterlars.mueller (at) uk-koeln.deUNSPECIFIED
Date:July 2013
Refereed publication:No
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Bone deformation, motion capturing, in-vivo
Event Title:19th IAA Humans in Space Symposium 2013
Event Location:Köln, Germany
Event Type:international Conference
Event Dates:7.-12. July 2013
Organizer:DLR
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W - no assignment
DLR - Research area:Space
DLR - Program:W - no assignment
DLR - Research theme (Project):W - no assignment (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Ganse, Bergita
Deposited On:15 Nov 2013 12:35
Last Modified:31 Jul 2019 19:42

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