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Tox-Box: securing drops of life - an enhanced
health-related approach for risk assessment of
drinking water in Germany
Tox-Box: Die Tropfen des Lebens
bewahren - Gesundheitsbasierte Risikobewertung
für Trinkwasser in Deutschland
Grummt, Tamara and Kuckelkorn, Jochen and Bahlmann, Arnold and Baumstark-Khan, Christa and Brack, Werner and Braunbeck, Thomas and Feles, Sebastian and Gartiser, Stefan and Glatt, Hansruedi and Heinze, Rita and Hellweg, Christine E and Hollert, Henner and Junek, Ralf and Knauer, Martina and Kneib-Kissinger, Birgit and Kramer, Meike and Krauss, Martin and Küster, Eberhard and Maletz, Sibylle and Meinl, Walter and Noman, Abu and Prantl, Eva-Maria and Rabbow, Elke and Redelstein, Regine and Rettberg, Petra and Schadenboeck, Walter and Schmidt, Carsten and Schulze, Tobias and Seiler, Thomas-Benjamin and Spitta, Luis and Stengel, Daniel and Waldmann, Petra and Eckhardt, Alexander
(2013)
Tox-Box: securing drops of life - an enhanced
health-related approach for risk assessment of
drinking water in Germany
Tox-Box: Die Tropfen des Lebens
bewahren - Gesundheitsbasierte Risikobewertung
für Trinkwasser in Deutschland.
Environmental Sciences Europe, 25 (27), pp. 1-8.
Springer.
doi: 10.1186/2190-4715-25-27.
ISSN 2190-4707.
Full text not available from this repository. AbstractThis article introduces ‘Tox-Box’, a joint research project designed to develop a holistic approach towards a
harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in
drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance
the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert)
through development and prioritization of additional end point-related testing strategies for genotoxicity,
neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be
identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and
weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance
document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water
will eventually be prepared. | Item URL in elib: | https://elib.dlr.de/84865/ |
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| Document Type: | Article |
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| Title: | Tox-Box: securing drops of life - an enhanced
health-related approach for risk assessment of
drinking water in Germany
Tox-Box: Die Tropfen des Lebens
bewahren - Gesundheitsbasierte Risikobewertung
für Trinkwasser in Deutschland |
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| Authors: | | Authors | Institution or Email of Authors | Author's ORCID iD | ORCID Put Code |
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| Grummt, Tamara | Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany. | UNSPECIFIED | UNSPECIFIED | | Kuckelkorn, Jochen | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. | UNSPECIFIED | UNSPECIFIED | | Bahlmann, Arnold | Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany. | UNSPECIFIED | UNSPECIFIED | | Baumstark-Khan, Christa | Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Brack, Werner | Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany. | UNSPECIFIED | UNSPECIFIED | | Braunbeck, Thomas | Aquatic Ecology & Toxicology, Centre for Organismal Studies (COS), University of Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany | UNSPECIFIED | UNSPECIFIED | | Feles, Sebastian | Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Gartiser, Stefan | Hydrotox GmbH, Bötzinger Str. 29, Freiburg im Breisgau 79111, Germany. | UNSPECIFIED | UNSPECIFIED | | Glatt, Hansruedi | Department of Nutritional Toxicology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany. | UNSPECIFIED | UNSPECIFIED | | Heinze, Rita | Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany. | UNSPECIFIED | UNSPECIFIED | | Hellweg, Christine E | Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Hollert, Henner | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. | UNSPECIFIED | UNSPECIFIED | | Junek, Ralf | Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany. | UNSPECIFIED | UNSPECIFIED | | Knauer, Martina | Hydrotox GmbH, Bötzinger Str. 29, Freiburg im Breisgau 79111, Germany. | UNSPECIFIED | UNSPECIFIED | | Kneib-Kissinger, Birgit | Cosmetical, Pharmaceutical and Toxicological Contract Research Laboratory and Consultancy, Incos Boté GmbH, Friedhofstr. 6, Alzey 55232, Germany. | UNSPECIFIED | UNSPECIFIED | | Kramer, Meike | Microbiology Department of the Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln 50823, Germany | UNSPECIFIED | UNSPECIFIED | | Krauss, Martin | Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany. | UNSPECIFIED | UNSPECIFIED | | Küster, Eberhard | Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr 15, Leipzig 04318, Germany. | UNSPECIFIED | UNSPECIFIED | | Maletz, Sibylle | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. | UNSPECIFIED | UNSPECIFIED | | Meinl, Walter | Department of Nutritional Toxicology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany. | UNSPECIFIED | UNSPECIFIED | | Noman, Abu | Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Prantl, Eva-Maria | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany and Microbiology Department of the Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln 50823, Germany | UNSPECIFIED | UNSPECIFIED | | Rabbow, Elke | Research Group Astrobiology, Department Radiation of Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Redelstein, Regine | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. | UNSPECIFIED | UNSPECIFIED | | Rettberg, Petra | Research Group Astrobiology, Department Radiation of Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Schadenboeck, Walter | Cosmetical, Pharmaceutical and Toxicological Contract Research Laboratory and Consultancy, Incos Boté GmbH, Friedhofstr. 6, Alzey 55232, Germany. | UNSPECIFIED | UNSPECIFIED | | Schmidt, Carsten | Microbiology Department of the Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln 50823, Germany | UNSPECIFIED | UNSPECIFIED | | Schulze, Tobias | Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany. | UNSPECIFIED | UNSPECIFIED | | Seiler, Thomas-Benjamin | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. | UNSPECIFIED | UNSPECIFIED | | Spitta, Luis | Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. | UNSPECIFIED | UNSPECIFIED | | Stengel, Daniel | Aquatic Ecology & Toxicology, Centre for Organismal Studies (COS), University of Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany | UNSPECIFIED | UNSPECIFIED | | Waldmann, Petra | Cosmetical, Pharmaceutical and Toxicological Contract Research Laboratory and Consultancy, Incos Boté GmbH, Friedhofstr. 6, Alzey 55232, Germany. | UNSPECIFIED | UNSPECIFIED | | Eckhardt, Alexander | Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany. | UNSPECIFIED | UNSPECIFIED |
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| Date: | 2013 |
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| Journal or Publication Title: | Environmental Sciences Europe |
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| Refereed publication: | Yes |
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| Open Access: | Yes |
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| Gold Open Access: | Yes |
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| In SCOPUS: | Yes |
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| In ISI Web of Science: | Yes |
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| Volume: | 25 |
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| DOI: | 10.1186/2190-4715-25-27 |
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| Page Range: | pp. 1-8 |
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| Editors: | | Editors | Email | Editor's ORCID iD | ORCID Put Code |
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| Hollert, Henner | Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. | UNSPECIFIED | UNSPECIFIED |
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| Publisher: | Springer |
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| ISSN: | 2190-4707 |
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| Status: | Published |
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| Keywords: | Tox-Box, risk assessment, drinking water, Germany, GOW-Konzept - Gesundheitlicher Orientierungswert, genotoxicity, neurotoxicity, germ cell damage, endocrine effects |
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| HGF - Research field: | Aeronautics, Space and Transport |
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| HGF - Program: | Space |
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| HGF - Program Themes: | Research under Space Conditions |
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| DLR - Research area: | Raumfahrt |
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| DLR - Program: | R FR - Research under Space Conditions |
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| DLR - Research theme (Project): | R - Vorhaben Strahlenbiologie (old) |
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|
Location: |
Köln-Porz
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| Institutes and Institutions: | Institute of Aerospace Medicine > Radiation Biology |
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| Deposited By: |
Kopp, Kerstin
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| Deposited On: | 15 Nov 2013 12:37 |
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| Last Modified: | 19 Mar 2019 05:02 |
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