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Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany Tox-Box: Die Tropfen des Lebens bewahren - Gesundheitsbasierte Risikobewertung für Trinkwasser in Deutschland

Grummt, Tamara and Kuckelkorn, Jochen and Bahlmann, Arnold and Baumstark-Khan, Christa and Brack, Werner and Braunbeck, Thomas and Feles, Sebastian and Gartiser, Stefan and Glatt, Hansruedi and Heinze, Rita and Hellweg, Christine E and Hollert, Henner and Junek, Ralf and Knauer, Martina and Kneib-Kissinger, Birgit and Kramer, Meike and Krauss, Martin and Küster, Eberhard and Maletz, Sibylle and Meinl, Walter and Noman, Abu and Prantl, Eva-Maria and Rabbow, Elke and Redelstein, Regine and Rettberg, Petra and Schadenboeck, Walter and Schmidt, Carsten and Schulze, Tobias and Seiler, Thomas-Benjamin and Spitta, Luis and Stengel, Daniel and Waldmann, Petra and Eckhardt, Alexander (2013) Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany Tox-Box: Die Tropfen des Lebens bewahren - Gesundheitsbasierte Risikobewertung für Trinkwasser in Deutschland. Environmental Sciences Europe, 25 (27), pp. 1-8. Springer. DOI: 10.1186/2190-4715-25-27 ISSN 2190-4707

Full text not available from this repository.

Abstract

This article introduces ‘Tox-Box’, a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert) through development and prioritization of additional end point-related testing strategies for genotoxicity, neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water will eventually be prepared.

Item URL in elib:https://elib.dlr.de/84865/
Document Type:Article
Title:Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany Tox-Box: Die Tropfen des Lebens bewahren - Gesundheitsbasierte Risikobewertung für Trinkwasser in Deutschland
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Grummt, Tamara Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany.UNSPECIFIED
Kuckelkorn, Jochen Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. UNSPECIFIED
Bahlmann, Arnold Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany.UNSPECIFIED
Baumstark-Khan, Christa Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. UNSPECIFIED
Brack, Werner Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany.UNSPECIFIED
Braunbeck, Thomas Aquatic Ecology & Toxicology, Centre for Organismal Studies (COS), University of Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany UNSPECIFIED
Feles, Sebastian Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. UNSPECIFIED
Gartiser, Stefan Hydrotox GmbH, Bötzinger Str. 29, Freiburg im Breisgau 79111, Germany. UNSPECIFIED
Glatt, Hansruedi Department of Nutritional Toxicology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany. UNSPECIFIED
Heinze, Rita Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany.UNSPECIFIED
Hellweg, Christine E Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. UNSPECIFIED
Hollert, Henner Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. UNSPECIFIED
Junek, Ralf Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany.UNSPECIFIED
Knauer, Martina Hydrotox GmbH, Bötzinger Str. 29, Freiburg im Breisgau 79111, Germany. UNSPECIFIED
Kneib-Kissinger, Birgit Cosmetical, Pharmaceutical and Toxicological Contract Research Laboratory and Consultancy, Incos Boté GmbH, Friedhofstr. 6, Alzey 55232, Germany. UNSPECIFIED
Kramer, Meike Microbiology Department of the Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln 50823, GermanyUNSPECIFIED
Krauss, Martin Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany.UNSPECIFIED
Küster, Eberhard Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr 15, Leipzig 04318, Germany. UNSPECIFIED
Maletz, Sibylle Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. UNSPECIFIED
Meinl, Walter Department of Nutritional Toxicology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany. UNSPECIFIED
Noman, Abu Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany.UNSPECIFIED
Prantl, Eva-Maria Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany and Microbiology Department of the Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln 50823, Germany UNSPECIFIED
Rabbow, Elke Research Group Astrobiology, Department Radiation of Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. UNSPECIFIED
Redelstein, Regine Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. UNSPECIFIED
Rettberg, Petra Research Group Astrobiology, Department Radiation of Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany.UNSPECIFIED
Schadenboeck, Walter Cosmetical, Pharmaceutical and Toxicological Contract Research Laboratory and Consultancy, Incos Boté GmbH, Friedhofstr. 6, Alzey 55232, Germany. UNSPECIFIED
Schmidt, Carsten Microbiology Department of the Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln 50823, GermanyUNSPECIFIED
Schulze, Tobias Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ,Permoserstr. 15, Leipzig 04318, Germany.UNSPECIFIED
Seiler, Thomas-Benjamin Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany. UNSPECIFIED
Spitta, Luis Research Group Cellular Biodiagnostics, Department of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Köln 51147, Germany. UNSPECIFIED
Stengel, Daniel Aquatic Ecology & Toxicology, Centre for Organismal Studies (COS), University of Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany UNSPECIFIED
Waldmann, Petra Cosmetical, Pharmaceutical and Toxicological Contract Research Laboratory and Consultancy, Incos Boté GmbH, Friedhofstr. 6, Alzey 55232, Germany. UNSPECIFIED
Eckhardt, Alexander Section Drinking Water and Swimming Pool Water Toxicology, Federal Environment Agency (UBA), Heinrich-Heine-Str. 12, Bad Elster 08645, Germany.UNSPECIFIED
Date:2013
Journal or Publication Title:Environmental Sciences Europe
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:25
DOI :10.1186/2190-4715-25-27
Page Range:pp. 1-8
Editors:
EditorsEmail
Hollert, Henner Institute for Environmental Research - Biology V, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany.
Publisher:Springer
ISSN:2190-4707
Status:Published
Keywords:Tox-Box, risk assessment, drinking water, Germany, GOW-Konzept - Gesundheitlicher Orientierungswert, genotoxicity, neurotoxicity, germ cell damage, endocrine effects
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:15 Nov 2013 12:37
Last Modified:19 Mar 2019 05:02

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