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Preparation of the Biochip experiment on the EXPOSE-R2 mission outside the International Space Station

Vigier, F. and Le Postollec, A. and Coussot, G. and Chaput, D. and Cottin, H. and Berger, T. and Incerti, S. and Triqueneaux, S. and Dobrijevic, M. and Vandenabeele-Trambouze, O. (2013) Preparation of the Biochip experiment on the EXPOSE-R2 mission outside the International Space Station. Advances in Space Research, 52 (12), pp. 2168-2179. Elsevier. DOI: 10.1016/j.asr.2013.09.026 ISSN 0273-1177

Full text not available from this repository.

Abstract

Biochips might be suited for planetary exploration. Indeed, they present great potential for the search for biomarkers – molecules that are the sign of past or present life in space – thanks to their size (miniaturized devices) and sensitivity. Their detection principle is based on the recognition of a target molecule by affinity receptors fixed on a solid surface. Consequently, one of the main concerns when developing such a system is the behavior of the biological receptors in a space environment. In this paper, we describe the preparation of an experiment planned to be part of the EXPOSE-R2 mission, which will be conducted on the EXPOSE-R facility, outside the International Space Station (ISS), in order to study the resistance of biochip models to space constraints (especially cosmic radiation and thermal cycling). This experiment overcomes the limits of ground tests which do not reproduce exactly the space parameters. Indeed, contrary to ground experiments where constraints are applied individually and in a limited time, the biochip models on the ISS will be exposed to cumulated constraints during several months. Finally, this ISS experiment is a necessary step towards planetary exploration as it will help assessing whether a biochip can be used for future exploration missions.

Item URL in elib:https://elib.dlr.de/84790/
Document Type:Article
Title:Preparation of the Biochip experiment on the EXPOSE-R2 mission outside the International Space Station
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Vigier, F.Institut des Biomolécules Max Mousseron-IBMM, Centre National de la Recherche Scientifique, Université de Montpellier 1, Université de Montpellier 2, Unité Mixte de Recherche 5247, place E. Bataillon, CC17006, 34095 Montpellier cedex 5, FranceUNSPECIFIED
Le Postollec, A.Univ. Bordeaux, LAB, UMR 5804, F-33270 Floirac, France and CNRS, LAB, UMR 5804, F-33270 Floirac, FranceUNSPECIFIED
Coussot, G.Institut des Biomolécules Max Mousseron-IBMM, Centre National de la Recherche Scientifique, Université de Montpellier 1, Université de Montpellier 2, Unité Mixte de Recherche 5247, place E. Bataillon, CC17006, 34095 Montpellier cedex 5, FranceUNSPECIFIED
Chaput, D.Centre National d’Etudes Spatiales (CNES), Centre Spatial de Toulouse, 18 Av. Edouard Belin, 31401 Toulouse Cedex 9, FranceUNSPECIFIED
Cottin, H.Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA), UMR CNRS 7583, Université Paris Est Créteil et Université Paris Diderot, Institut Pierre Simon Laplace, FranceUNSPECIFIED
Berger, T.German Aerospace Center, Institute of Aerospace Medicine, D-51147 Cologne, GermanyUNSPECIFIED
Incerti, S.Université Bordeaux 1, CNRS, IN2P3, Centre d’Etudes Nucléaires de Bordeaux Gradignan (CENBG), UMR 5797, Gradignan, FranceUNSPECIFIED
Triqueneaux, S.Air Liquide Advanced Technologies, 2 Rue de Clémencière, 38360 Sassenage, FranceUNSPECIFIED
Dobrijevic, M.Univ. Bordeaux, LAB, UMR 5804, F-33270 Floirac, France and CNRS, LAB, UMR 5804, F-33270 Floirac, FranceUNSPECIFIED
Vandenabeele-Trambouze, O.Institut des Biomolécules Max Mousseron-IBMM, Centre National de la Recherche Scientifique, Université de Montpellier 1, Université de Montpellier 2, Unité Mixte de Recherche 5247, place E. Bataillon, CC17006, 34095 Montpellier cedex 5, FranceUNSPECIFIED
Date:2013
Journal or Publication Title:Advances in Space Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:52
DOI :10.1016/j.asr.2013.09.026
Page Range:pp. 2168-2179
Publisher:Elsevier
ISSN:0273-1177
Status:Published
Keywords:EXPOSE-R2 mission, ISS, Biochip, Antibodies and aptamers, Space constraints, Cosmic radiation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:25 Oct 2013 11:50
Last Modified:06 Sep 2019 15:27

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