DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Muscle x-ray attenuation is not decreased during experimental bed rest.

Rittweger, Jörn and Müller, Klaus and Bareille, MARIE-PIERRE and Felsenberg, Dieter (2013) Muscle x-ray attenuation is not decreased during experimental bed rest. Muscle & Nerve (47), pp. 722-730. Wiley. DOI: DOI 10.1002/mus.23644 ISSN 0148-639X

[img] PDF


Muscle X-ray attenuation (MXA) in Hounsfield units (HU) is decreased in dystrophy, aging, and immobilization. We hypothesized a decrease also during bed rest (BR). Methods: Twenty-five healthy men performed BR for 90 days, 8 of whom performed flywheel exercise 2–3 times per week. Muscle cross-sectional area (CSA) and MXA were assessed by computed tomography. Results: In the control group, calf muscle CSA decreased during 89-day BR by 26.6 (SD 3.8) %, while MXA increased by 1.2 HU on day 28 and almost reached baseline values on day 89. Changes were mitigated in the flywheel group for the calf (P < 0.001). All changes were reversed within 90 days after BR. Conclusions: Results contradict the initial hypothesis. Increased intramuscular blood content, interstitial fluid space shrinkage, and reduction of intramuscular lipid stores are possible explanations for the moderate increase in MXA during the initial phase of bed rest.

Item URL in elib:https://elib.dlr.de/82162/
Document Type:Article
Title:Muscle x-ray attenuation is not decreased during experimental bed rest.
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Müller, Klausklaus.mueller (at) dlr.deUNSPECIFIED
Felsenberg, DieterCharité - University Medicine BerlinUNSPECIFIED
Date:May 2013
Journal or Publication Title:Muscle & Nerve
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:Yes
DOI :DOI 10.1002/mus.23644
Page Range:pp. 722-730
Phillips II, Lawrence H.UNSPECIFIED
Keywords:blood content, human physiology, immobilization, physical medicine, peripheral quantitative computed tomography
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:27 May 2013 15:30
Last Modified:06 Sep 2019 15:28

Repository Staff Only: item control page

Help & Contact
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.