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Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men

Frings-Meuthen, Petra and Boehme, Gisela and Liphardt, Anna-Maria and Heer, M. and Rittweger, Jörn (2013) Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men. Journal of Musculoskeletal and Neuronal Interactions, 13 (1), pp. 45-52. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161

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Abstract

Objectives: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people. Methods: Two bed rest studies were conducted at the German Aerospace Center in Cologne. 14 days of 6° head-down-tilt bed rest were applied to eight healthy young male test subjects in study 1 and 21 days of head-down-tilt bed rest to seven healthy male subjects in study 2. Results: Sclerostin levels increased in both studies during bed rest (study 1, 0.64±0.05 ng/ml to 0.69±0.04 ng/ml, P=0.014; study 2, 0.42±0.04 ng/ml to 0.47±0.04 ng/ml, P=0.008) and they declined at the end of the 14- and 21-day bed rest periods. DKK1 decreased during the bed rest period in study 1 (P<0.001) but increased during bed rest in study 2 (P=0.006). As expected, bone formation marker PINP decreased (study 1, P=0.013; study 2, P<0.001) and bone resorption marker NTX increased during bed rest (P<0.001). Conclusion: Data suggest that the Wnt signaling pathway is involved in disuse-induced bone loss in young, healthy humans.

Item URL in elib:https://elib.dlr.de/81468/
Document Type:Article
Title:Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Frings-Meuthen, PetraMEUNSPECIFIED
Boehme, GiselaMEUNSPECIFIED
Liphardt, Anna-MariaUNSPECIFIEDUNSPECIFIED
Heer, M.UNSPECIFIEDUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Date:2013
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:13
Page Range:pp. 45-52
Editors:
EditorsEmail
Jee, Webster S.S.UNSPECIFIED
Publisher:International Society of Musculoskeletal and Neuronal Interactions
ISSN:1108-7161
Status:Published
Keywords:Sclerostin, DKK1, Bone Metabolism, Immobilization, Wnt Signaling
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:04 Mar 2013 07:59
Last Modified:10 Jan 2019 15:51

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