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A Cross-Sectional Study of the Relationship between Cortical Bone and High-Impact Activity in Young Adult Males and Females

Deere, K. and Sayers, A. and Rittweger, Jörn and Tobias, J. H. (2013) A Cross-Sectional Study of the Relationship between Cortical Bone and High-Impact Activity in Young Adult Males and Females. Journal of Clinical Endocrinology and Metabolism (97(10)), pp. 3734-3743. The Endocrine Society. DOI: 10.1210/jc.2012-1752 ISSN 0021-972X

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Official URL: http://jcem.endojournals.org

Abstract

Sexual dimorphism in skeletal development is well recognized and likely to contribute to gender differences in fracture risk (1), such as the relatively high risk of hip fractures in elderlywomen(2). At the hip, these differences have been reported to emerge during the adolescent growth spurt and to be comprised largely of greater periosteal apposition in males, leading to greater femoral neck width and bending strength (3). More rapid periosteal boneformationin males, leading to greater corticalbonesize, has also been reported at the mid-femur (prepubertal children and young adults combined) (4), mid-tibia (peripubertal children) (5),anddistal tibiaandfemoral neck (18 yr olds) (6). Our previous cross-sectional study of hip structure in peripubertal children from the Avon Longitudinal Study of Parents and Children (ALSPAC) revealed that emergence of these differences coincided with the onset of puberty (7).Any suggestion that sex steroids contribute to sexual dimorphism of the skeleton is consistent with previous findings from rodent studies suggesting that estrogens and androgens respectively suppress and stimulate periosteal growth (8, 9).

Item URL in elib:https://elib.dlr.de/80795/
Document Type:Article
Title:A Cross-Sectional Study of the Relationship between Cortical Bone and High-Impact Activity in Young Adult Males and Females
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Deere, K.UNSPECIFIEDUNSPECIFIED
Sayers, A.UNSPECIFIEDUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Tobias, J. H.UNSPECIFIEDUNSPECIFIED
Date:October 2013
Journal or Publication Title:Journal of Clinical Endocrinology and Metabolism
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1210/jc.2012-1752
Page Range:pp. 3734-3743
Publisher:The Endocrine Society
ISSN:0021-972X
Status:Published
Keywords:Cortical Bone High Impact Activity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):Vorhaben Knocheneigenschaften
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:21 Jan 2013 10:23
Last Modified:06 Sep 2019 15:22

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