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Site and sex effects on tibia structure in runners and untrained people

Feldman, Sara und Capozza, Ricardo und Mortarino, Pablo und Reina, Paola und Ferretti, José Luis und Rittweger, Jörn und Cointry, Gustavo (2012) Site and sex effects on tibia structure in runners and untrained people. Medicine and Science in Sports and Exercise, 8, Seiten 1580-1288. Lippincott Williams & Wilkins Ltd.. ISSN 0025-7990

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PURPOSE: The purpose was to study the relationship between mechanical environment and bone structure by comparing the tibia in people with different physical activities. MATERIALS AND METHODS: Indicators of bone mass (bone mineral content), bone material "quality" (cortical volumetric mineral density (vBMD)), and diaphyseal design (endocortical and periosteal perimeters (EcPm and PoPm, respectively), cortical thickness (CtTh), circularity, and bending and torsion cross-sectional moments of inertia (CSMIs)) were determined in serial peripheral quantitative computed tomography scans taken at 5% steps of the tibia in 40 voluntary men and women age 25-40 yr who were either physically inactive or experienced distance runners (n = 10-12 per group). RESULTS: Bone mass and design indicators were higher in runner than in nonrunner men, with a variable effect size along the tibia. In the distal tibia, runners had enhanced bone mineral content and CtTh (resistance to compression), but EcPm, PoPm, circularity, and CSMI were unaffected. In the midshaft, CSMIs (resistance to bending/torsion) were enhanced in runners, whereas bone mass was unaffected. In the proximal third, effects were observed for CtTh, EcPm, and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex. DISCUSSION: Results are coherent with previous findings in physically inactive people and with Frost's mechanostat theory. The observed group differences in cortical vBMD could reflect an increase in intracortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMI improvements. The sex specificity of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.

Titel:Site and sex effects on tibia structure in runners and untrained people
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iD
Feldman, SaraUniversity of RosarioNICHT SPEZIFIZIERT
Capozza, RicardoUniversity of RosarioNICHT SPEZIFIZIERT
Mortarino, PabloUniversity of RosarioNICHT SPEZIFIZIERT
Reina, PaolaUniversity of RosarioNICHT SPEZIFIZIERT
Ferretti, José LuisUniversity of RosarioNICHT SPEZIFIZIERT
Rittweger, Jörnjoern.rittweger@dlr.deNICHT SPEZIFIZIERT
Cointry, GustavoUniversity of RosarioNICHT SPEZIFIZIERT
Erschienen in:Medicine and Science in Sports and Exercise
Referierte Publikation:Ja
In ISI Web of Science:Nein
Seitenbereich:Seiten 1580-1288
Verlag:Lippincott Williams & Wilkins Ltd.
Name der Reihe:44
Stichwörter:Exercise and bone, Osteopenia, Osteoporosis, Bone biomechanics, bone structure, bone strength
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Rittweger, Jörn
Hinterlegt am:14 Sep 2012 12:00
Letzte Änderung:08 Mär 2018 18:27

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