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Site and sex effects on tibia structure in runners and untrained people

Feldman, Sara and Capozza, Ricardo and Mortarino, Pablo and Reina, Paola and Ferretti, José Luis and Rittweger, Jörn and Cointry, Gustavo (2012) Site and sex effects on tibia structure in runners and untrained people. Medicine and Science in Sports and Exercise, 8, pp. 1580-1288. Lippincott Williams & Wilkins Ltd.. doi: 10.1249/mss.0b013e31824e10b6. ISSN 0025-7990.

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PURPOSE: The purpose was to study the relationship between mechanical environment and bone structure by comparing the tibia in people with different physical activities. MATERIALS AND METHODS: Indicators of bone mass (bone mineral content), bone material "quality" (cortical volumetric mineral density (vBMD)), and diaphyseal design (endocortical and periosteal perimeters (EcPm and PoPm, respectively), cortical thickness (CtTh), circularity, and bending and torsion cross-sectional moments of inertia (CSMIs)) were determined in serial peripheral quantitative computed tomography scans taken at 5% steps of the tibia in 40 voluntary men and women age 25-40 yr who were either physically inactive or experienced distance runners (n = 10-12 per group). RESULTS: Bone mass and design indicators were higher in runner than in nonrunner men, with a variable effect size along the tibia. In the distal tibia, runners had enhanced bone mineral content and CtTh (resistance to compression), but EcPm, PoPm, circularity, and CSMI were unaffected. In the midshaft, CSMIs (resistance to bending/torsion) were enhanced in runners, whereas bone mass was unaffected. In the proximal third, effects were observed for CtTh, EcPm, and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex. DISCUSSION: Results are coherent with previous findings in physically inactive people and with Frost's mechanostat theory. The observed group differences in cortical vBMD could reflect an increase in intracortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMI improvements. The sex specificity of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.

Item URL in elib:https://elib.dlr.de/77265/
Document Type:Article
Title:Site and sex effects on tibia structure in runners and untrained people
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Feldman, SaraUniversity of RosarioUNSPECIFIEDUNSPECIFIED
Capozza, RicardoUniversity of RosarioUNSPECIFIEDUNSPECIFIED
Mortarino, PabloUniversity of RosarioUNSPECIFIEDUNSPECIFIED
Reina, PaolaUniversity of RosarioUNSPECIFIEDUNSPECIFIED
Ferretti, José LuisUniversity of RosarioUNSPECIFIEDUNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Cointry, GustavoUniversity of RosarioUNSPECIFIEDUNSPECIFIED
Journal or Publication Title:Medicine and Science in Sports and Exercise
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:No
Page Range:pp. 1580-1288
Publisher:Lippincott Williams & Wilkins Ltd.
Series Name:44
Keywords:Exercise and bone, Osteopenia, Osteoporosis, Bone biomechanics, bone structure, bone strength
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Rittweger, Jörn
Deposited On:14 Sep 2012 12:00
Last Modified:20 Nov 2023 15:24

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