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Van der Meer, S.F. and Degens, H. (2011) Is the myonuclear domain size fixed? Journal of Musculoskeletal and Neuronal Interactions, 11 (4). ISSN 1108-7161
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Abstract
It has been suggested that the number of myonuclei in a muscle fibre changes in proportion to the change in fibre size, resulting in a constant myonuclear domain size, defined as the cytoplasmic volume per myonucleus. The myonuclear domain size varies, however, between fibre types and is inversely related with the oxidative capacity of a fibre. Overall, the observations of an increase in myonuclear domain size during both maturational growth and overload-induced hypertrophy, and the decrease in myonuclear domain size during disuse- and ageing-associated muscle atrophy suggest that the concept of a constant myonuclear domain size needs to be treated cautiously. It also suggests that only when the myonuclear domain size exceeds a certain threshold during growth or overload-induced hypertrophy acquisition of new myonuclei is required for further fibre hypertrophy.
| Item URL in elib: | https://elib.dlr.de/74643/ | |||||||||
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| Document Type: | Article | |||||||||
| Title: | Is the myonuclear domain size fixed? | |||||||||
| Authors: |
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| Date: | December 2011 | |||||||||
| Journal or Publication Title: | Journal of Musculoskeletal and Neuronal Interactions | |||||||||
| Refereed publication: | Yes | |||||||||
| Open Access: | No | |||||||||
| Gold Open Access: | No | |||||||||
| In SCOPUS: | No | |||||||||
| In ISI Web of Science: | Yes | |||||||||
| Volume: | 11 | |||||||||
| ISSN: | 1108-7161 | |||||||||
| Status: | Published | |||||||||
| Keywords: | Skeletal Muscle Myonuclear Domain Satellite Cell Hypertrophy Atrophy Ageing Growth | |||||||||
| HGF - Research field: | other | |||||||||
| HGF - Program: | other | |||||||||
| HGF - Program Themes: | other | |||||||||
| DLR - Research area: | no assignment | |||||||||
| DLR - Program: | no assignment | |||||||||
| DLR - Research theme (Project): | no assignment | |||||||||
| Location: | Köln-Porz | |||||||||
| Institutes and Institutions: | Institute of Aerospace Medicine > Space Physiology | |||||||||
| Deposited By: | Müller, Klaus | |||||||||
| Deposited On: | 30 Jan 2012 11:23 | |||||||||
| Last Modified: | 07 Feb 2013 19:27 |
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