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Time course of myonuclear accretion during hypertrophy in young-adult and older rat plantaris muscle

Van der Meer, S.F. and Jaspers, R.T. and Jones, D.A. and Degens, H. (2011) Time course of myonuclear accretion during hypertrophy in young-adult and older rat plantaris muscle. Annals of Anatomy - Anatomischer Anzeiger, 193 (1), pp. 56-63. ISSN 0940-9602

Full text not available from this repository.

Abstract

To investigate whether accretion of myonuclei precedes or follows the increase in fibre cross-sectional area and whether this time course is affected by age, left plantaris muscle of 5- and 25-month-old male Wistar rats was overloaded by denervation of its synergists for 1, 2 or 4 weeks. Contralateral plantaris muscle served as control. Myonuclei were counted in haematoxylin-stained cross-sections. While hypertrophy (33% in young adult) became significant after 2 weeks overload (p<0.01), the myonuclear number was increased only at 4 weeks of overload (p<0.001). The time course and magnitude of hypertrophy were similar in young adult and older rats. Older muscles contained 26% more myonuclei per mm fibre length (p=0.001) and had a 10-fold larger proportion of central myonuclei (p<0.001) than young adult muscles. In conclusion, our data indicate that muscle fibre hypertrophy precedes the acquisition of new myonuclei and that the ability to develop hypertrophy is not attenuated or delayed in 25-month-old rat muscle.

Item URL in elib:https://elib.dlr.de/74640/
Document Type:Article
Title:Time course of myonuclear accretion during hypertrophy in young-adult and older rat plantaris muscle
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Van der Meer, S.F.UNSPECIFIEDUNSPECIFIED
Jaspers, R.T.UNSPECIFIEDUNSPECIFIED
Jones, D.A.UNSPECIFIEDUNSPECIFIED
Degens, H.UNSPECIFIEDUNSPECIFIED
Date:February 2011
Journal or Publication Title:Annals of Anatomy - Anatomischer Anzeiger
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:193
Page Range:pp. 56-63
ISSN:0940-9602
Status:Published
Keywords: * Aging/pathology* * Animals * Cell Nucleus/pathology* * Hindlimb/pathology * Male * Muscle, Skeletal/pathology* * Muscular Disorders, Atrophic/pathology* * Rats * Rats, Wistar
HGF - Research field:other
HGF - Program:other
HGF - Program Themes:other
DLR - Research area:no assignment
DLR - Program:no assignment
DLR - Research theme (Project):no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Müller, Klaus
Deposited On:30 Jan 2012 11:24
Last Modified:07 Feb 2013 19:17

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