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Noninvasive Estimation of Myosin Heavy Chain Composition in Human Skeletal Muscle

Simunic, Bostjan and Degens, Hans and Rittweger, Jörn and Narici, Marco and Mekjavic, Igor and Pisot, Rado (2011) Noninvasive Estimation of Myosin Heavy Chain Composition in Human Skeletal Muscle. Medicine and Science in Sports and Exercise, 43 (9), pp. 1619-1625. Lippincott Williams & Wilkins Ltd.. ISSN 0025-7990

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Abstract

Purpose: Information on muscle fiber type composition is of great importance in muscle physiology and athletic performance. Because there are only a few techniques available that noninvasively and accurately provide an estimate of muscle fiber type composition, the development of additional and alternative approaches is required. Methods: Twenty-seven participants (21 men, 6 women) with an average age of 43 T 18 yr, height of 175 T 7 cm, and mass of 74 T 12 kg participated in the study. Delay, contraction, and half relaxation times were calculated from tensiomyographic radial twitch responses of the vastus lateralis muscle. Univariate and multiple linear regression analyses were used to correlate the proportion of myosin heavy chain I (%MHC-I) in a biopsy obtained from the same muscle with a single and all three radial twitch parameters. Results: Delay, contraction, and half relaxation times all correlated with %MHC-I (r = 0.612, 0.878, and 0.669, respectively, at P e 0.001). When all three parameters were included in a multiple linear regression, the correlation with the %MHC-I was even better (R = 0.933, P G 0.001). Conclusions: These data suggest that time parameters of the skeletal muscle mechanical radial twitch response, measured with a contact linear displacement sensor, can be used as an accurate noninvasive predictor of the %MHC-I in a muscle.

Item URL in elib:https://elib.dlr.de/72341/
Document Type:Article
Title:Noninvasive Estimation of Myosin Heavy Chain Composition in Human Skeletal Muscle
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Simunic, BostjanUniversity of PrimorskaUNSPECIFIED
Degens, HansManchester Metropolitan UniversityUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Narici, MarcoManchester Metropolitan University, U.K.UNSPECIFIED
Mekjavic, IgorJozef Stefan InstituteUNSPECIFIED
Pisot, RadoUniversity of PrimorskaUNSPECIFIED
Date:2011
Journal or Publication Title:Medicine and Science in Sports and Exercise
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:No
Volume:43
Page Range:pp. 1619-1625
Publisher:Lippincott Williams & Wilkins Ltd.
ISSN:0025-7990
Status:Published
Keywords:TENSIOMYOGRAPHY, FIBER TYPE, MYOSIN HEAVY CHAIN, MECHANOMYOGRAPHY
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Rittweger, Jörn
Deposited On:06 Dec 2011 12:21
Last Modified:06 Sep 2019 15:28

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