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Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength

Flueck, Martin and Eyeang-Békalé, Nadège and Héraud, Audrey and Girard, Anne and Gimpl, Martin and Seynnes, Olivier and Rittweger, Jörn and Niebauer, Josef and Mueller, Erich and Narici, Marco (2011) Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength. Scandinavian Journal of Medicine & Science in Sports, 23 (Suppl ), pp. 29-38. Wiley.

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Abstract

We hypothesized that 3-months of downhill skiing mitigates functional deficits of knee extensor muscles in elderly subjects due to specific recruitment of fast motor units during forceful turns on the slope. Downhill skiing lead to a 1.4-fold increase in mean cross sectional area of slow (p=0.04) and fast (p=0.08) type muscle fibres. Fold changes in the structural component of focal adhesions, gamma-vinculin, correlated with alterations in concentric force (r=0.64). Hypertrophy of fast fibres was more important in women than in men (1.7 vs. 1.1). Gender specific structural-functional adjustments of extensor muscle and attached patellar tendon were reflected by altered expression of pro- vs. de-adhesive proteins and a number of correlations. The de-adhesive protein tenascin-C was selectively increased in women compared to men (1.7 vs. 1.1) while the content of the adhesive collagen XII was specifically reduced by 39% in women. The pro-adhesive focal adhesion kinase showed a specific increase in men (1.9 vs. 1.1). Our findings identify that quantitatively matched adaptations in slow and fast motor units underlie the preventive effect of skiing against sarcopenia and support that hypertrophy and reinforcement of fibre adhesion in extensor muscle are two myocellular strategies which operate in the improvement of muscle strength.

Item URL in elib:https://elib.dlr.de/70416/
Document Type:Article
Title:Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Flueck, MartinManchester Metropolitan UniversityUNSPECIFIED
Eyeang-Békalé, NadègeManchester Metropolitan UniversityUNSPECIFIED
Héraud, AudreyManchester Metropolitan UniversityUNSPECIFIED
Girard, AnneManchester Metropolitan UniversityUNSPECIFIED
Gimpl, MartinUniversity of SalzburgUNSPECIFIED
Seynnes, OlivierManchester Metropolitan UniversityUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Niebauer, JosefUniversity of SalzburgUNSPECIFIED
Mueller, ErichUniversity of SalzburgUNSPECIFIED
Narici, MarcoManchester Metropolitan UniversityUNSPECIFIED
Date:2011
Journal or Publication Title:Scandinavian Journal of Medicine & Science in Sports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:23
Page Range:pp. 29-38
Publisher:Wiley
Status:Published
Keywords:muscle, human, eccentric, extracellular matrix, focal adhesion, costamere, tenascin-C, focal adhesion kinase
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Rittweger, Jörn
Deposited On:09 Sep 2011 09:16
Last Modified:06 Sep 2019 15:21

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