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Anatomical sector analysis of load-bearing tibial bone structure during 90 days bed rest and 1- year recovery

Cervinka, Tomas and Rittweger, Jörn and Hyttinen, Jari and Felsenberg, Dieter and Sievänen, Harrir (2011) Anatomical sector analysis of load-bearing tibial bone structure during 90 days bed rest and 1- year recovery. Clinical Physiology and Functional Imaging, 31, pp. 249-257. Wiley.

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Abstract

The aim of this study was to investigate whether the bone response to long bed rest–related immobility and during subsequent recovery differed at anatomically different sectors of tibial epiphysis and diaphysis. For this study, peripheral quantitative tomographic (pQCT) scans obtained from a previous 90-day Long Term Bed Rest intervention were preprocessed with a new method based on statistical approach and re-analysed sector-wise. The pQCT was performed on 25 young healthy males twice before the bed rest, after the bed rest and after 1-year follow-up. All men underwent a strict bed rest intervention, and in addition, seven of them received pamidronate treatment and nine did flywheel exercises as countermeasures against disuse-related bone loss. Clearly, 3–9% sector-specific losses in trabecular density were observed at the tibial epiphysis on average. Similarly, cortical density decreased in a sectorspecific way being the largest at the anterior sector of tibial diaphysis. During recovery, the bed rest–induced bone losses were practically restored and no consistent sector-specific modulation was observed in any subgroup. It is concluded that the sector-specific analysis of bone cross-sections has potential to reveal skeletal responses to various interventions that cannot be inferred from the average analysis of the whole bone cross-section. This approach is considered also useful for evaluating the bone responses from the biomechanical point of view.

Item URL in elib:https://elib.dlr.de/70108/
Document Type:Article
Title:Anatomical sector analysis of load-bearing tibial bone structure during 90 days bed rest and 1- year recovery
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Cervinka, TomasTampere University of TechnologyUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Hyttinen, JariTampere University of TechnologyUNSPECIFIED
Felsenberg, DieterCharité Campus Benjamin FranklinUNSPECIFIED
Sievänen, HarrirUKK InstituteUNSPECIFIED
Date:2011
Journal or Publication Title:Clinical Physiology and Functional Imaging
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:31
Page Range:pp. 249-257
Publisher:Wiley
Status:Published
Keywords:bone loss; cortical bone; disuse; image preprocessing; trabecular bone
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Rittweger, Jörn
Deposited On:27 Jun 2011 09:15
Last Modified:31 Jul 2019 19:32

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