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Carbon-Ion-Induced Activation of the NF-kB Pathway

Hellweg, Christine E. and Baumstark-Khan, Christa and Schmitz, Claudia and Lau, Patrick and Meier, Matthias M. and Testard, Isabelle and Berger, Thomas and Reitz, Günther (2011) Carbon-Ion-Induced Activation of the NF-kB Pathway. Radiation Research, 175 (4), pp. 424-431. Radiation Research Society. DOI: 10.1667/RR2423.1

Full text not available from this repository.

Abstract

Carbon-ion cancer therapy offers several physical and radiobiological advantages over conventional photon cancer therapy. The molecular mechanisms that determine cellular outcome, including the activation of transcription factors and the alteration of gene expression profiles, after carbon-ion exposure are still under investigation. We have previously shown that argon ions (LET 272 keV/µm) had a much higher potential to activate the transcription factor nuclear factor κB (NF-κB) than X rays. NF-κB is involved in the regulation of cellular survival, mostly by antiapoptosis and cell cycle-regulating target genes, which are important in the resistance of cancer cells to radiotherapy. Therefore, activation of the NF-κB pathway by accelerated carbon ions (LET 33 and 73 keV/µm) was examined. For comparison, cells were exposed to 150 kV X rays and to accelerated carbon ions. NF-κB-dependent gene induction after exposure was detected in stably transfected human 293 reporter cells. Carbon ions and X rays had a comparable potential to activate NF-κB in human cells, indicating a comparable usefulness of pharmacological NF-κB inhibition during photon and carbon-ion radiotherapy.

Item URL in elib:https://elib.dlr.de/69549/
Document Type:Article
Title:Carbon-Ion-Induced Activation of the NF-kB Pathway
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hellweg, Christine E. UNSPECIFIEDUNSPECIFIED
Baumstark-Khan, Christa UNSPECIFIEDUNSPECIFIED
Schmitz, Claudia UNSPECIFIEDUNSPECIFIED
Lau, Patrick UNSPECIFIEDUNSPECIFIED
Meier, Matthias M. UNSPECIFIEDUNSPECIFIED
Testard, Isabelle Laboratoire d’Accueil en Radiobiologie avec les Ions Accélérés (LARIA), CEA, DVS/IRCM au CIMAP/GANIL, 14070 Caen Cedex, FranceUNSPECIFIED
Berger, Thomas UNSPECIFIEDUNSPECIFIED
Reitz, GüntherUNSPECIFIEDUNSPECIFIED
Date:2011
Journal or Publication Title:Radiation Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:175
DOI :10.1667/RR2423.1
Page Range:pp. 424-431
Publisher:Radiation Research Society
Status:Published
Keywords:Carbon-ions , X rays , NF-κB, photon and carbon-ion radiotherapy
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:16 Jun 2011 12:33
Last Modified:04 Apr 2013 16:28

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