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The 2nd Berlin BedRest study: protocol and implementation

Belavy, Daniel and Bock, Oliver and Börst, Hendrikje and Armbrecht, Gabriele and Gast, Ulf and Degner, Corinna and Beller, Gisela and Soll, Henning and Salanova, Michele and Habazettl, Helmut and Heer, Martina and de Haan, Arnold and Stegeman, Dick F and Cerretelli, Paolo and Blottner, Dieter and Rittweger, Jörn and Gelfi, Cecilia and Kornak, Uwe and Felsenberg, Dieter (2010) The 2nd Berlin BedRest study: protocol and implementation. Journal of Musculoskeletal and Neuronal Interactions, 10 (3), pp. 207-219. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161.

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Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p<.0001), though similarly in all groups (p≥.17). Body weight changes differed between groups (p<.0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVEgroup displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest ethodology are also discussed.

Item URL in elib:https://elib.dlr.de/65638/
Document Type:Article
Title:The 2nd Berlin BedRest study: protocol and implementation
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Belavy, DanielCharite - University Medicine BerlinUNSPECIFIED
Bock, OliverCharite - University Medicine BerlinUNSPECIFIED
Börst, HendrikjeCharite - University Medicine BerlinUNSPECIFIED
Armbrecht, GabrieleCharite - University Medicine BerlinUNSPECIFIED
Gast, UlfCharite - University Medicine BerlinUNSPECIFIED
Degner, CorinnaCharite - University Medicine BerlinUNSPECIFIED
Beller, GiselaCharite - University Medicine BerlinUNSPECIFIED
Soll, Henninghenning.soll (at) dlr.deUNSPECIFIED
Salanova, MicheleCharite - University Medicine BerlinUNSPECIFIED
Habazettl, HelmutCharite - University Medicine BerlinUNSPECIFIED
Heer, MartinaProfil ResearchUNSPECIFIED
de Haan, ArnoldFree University AmsterdamUNSPECIFIED
Stegeman, Dick FNijmegen UniversityUNSPECIFIED
Cerretelli, PaoloUniversity MilanUNSPECIFIED
Blottner, DieterCharite - University Medicine BerlinUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Gelfi, CeciliaUniversity MilanUNSPECIFIED
Kornak, UweCharite - University Medicine BerlinUNSPECIFIED
Felsenberg, DieterCharite - University Medicine BerlinUNSPECIFIED
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 207-219
Publisher:International Society of Musculoskeletal and Neuronal Interactions
Keywords:Spaceflight, Microgravity, Countermeasures, Inactivity, Exercise
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Rittweger, Jörn
Deposited On:11 Oct 2010 09:25
Last Modified:10 Jan 2019 15:51

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