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Resistive vibration exercise attenuates bone and muscle atrophy in 56-days of bed-rest: whole body DXA and biochemical markers of bone metabolism

Armbrecht, Gabriele and Belavy, Daniel Ludovic and Gast, Ulf and Bongrazio, Martina and Touby, Frank and Beller, Gise and Roth, H.J. and Perschel, Frank H. and Rittweger, Jörn and Felsenberg, Dieter (2010) Resistive vibration exercise attenuates bone and muscle atrophy in 56-days of bed-rest: whole body DXA and biochemical markers of bone metabolism. Osteoporosis International, 21 (4), pp. 597-607. Springer.

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Abstract

Summary During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation. Introduction To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints. Methods Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest. Results Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (−1.8(0.9)%, p = 0.042) whereas the RVE group did not (−0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12). Conclusions The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.

Item URL in elib:https://elib.dlr.de/63896/
Document Type:Article
Title:Resistive vibration exercise attenuates bone and muscle atrophy in 56-days of bed-rest: whole body DXA and biochemical markers of bone metabolism
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Armbrecht, GabrieleCharité Campus Benjamin FranklinUNSPECIFIED
Belavy, Daniel LudovicCharité Campus Benjamin FranklinUNSPECIFIED
Gast, UlfCharité Campus Benjamin FranklinUNSPECIFIED
Bongrazio, MartinaCharité Campus Benjamin FranklinUNSPECIFIED
Touby, FrankCharité Campus Benjamin FranklinUNSPECIFIED
Beller, GiseCharité Campus Benjamin FranklinUNSPECIFIED
Roth, H.J.Labor LimbachUNSPECIFIED
Perschel, Frank H.Charité Campus Benjamin FranklinUNSPECIFIED
Rittweger, JörnManchester Metropolitan UniversityUNSPECIFIED
Felsenberg, DieterCharité Campus Benjamin FranklinUNSPECIFIED
Date:April 2010
Journal or Publication Title:Osteoporosis International
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:21
Page Range:pp. 597-607
Publisher:Springer
Status:Published
Keywords:Bone turnover markers - DXA - Microgravity - Re-ambulation - Vibration exercise
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Rittweger, Jörn
Deposited On:28 Apr 2010 12:20
Last Modified:06 Sep 2019 15:20

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