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Toxicity of combustion condensates on human cells

Stojičić, Nevena (2009) Toxicity of combustion condensates on human cells. Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.

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Combustion exhausts emitted from traffic and industry sources represent the main contributors to air pollution in urban areas, and as such they have been associated with increased mortality and cardiorespiratory morbidity. Despite intense research, the mechanism of these correlations is still not fully understood. Most of the studies published so far have focused their research on only soot particles or their surrogates (e.g. carbon black), thereby neglecting other combustion by-products present in exhausts. The “cool trap” method, applied in this work, collects particulate and gaseous components of the combustion exhaust. Utilisation of such heterogeneous mixtures can give a better insight in the toxicity of combustion exhausts. The main aim of this work was to study the toxicity of combustion condensates on human alveolar (A-549) and human monocyte-like (U-937) cell lines. The combustion condensates originated from premixed ethylene/oxygen laboratory flames or from diesel fuel combustion. Pre-screening of toxicity was performed by using bacterial SWITCH test which utilises the recombinant S. typhimurium TA1535 pSWITCH strain.

Item URL in elib:https://elib.dlr.de/63773/
Document Type:Thesis (Dissertation)
Title:Toxicity of combustion condensates on human cells
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Open Access:No
Gold Open Access:No
In ISI Web of Science:No
Number of Pages:151
Keywords:Human cells, Toxicity of combustion condensates, Air pollution, Health impacts
Institution:Rheinische Friedrich-Wilhelms-Universität Bonn
Department:Mathematisch-Naturwissenschaftliche Fakultät
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:12 Apr 2010 13:31
Last Modified:12 Apr 2010 13:31

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