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PMT (Photomultiplier) Clinostat

Horn, Astrid and Ullrich, Oliver and Huber, Kathrin and Hemmersbach, Ruth (2011) PMT (Photomultiplier) Clinostat. Microgravity Science and Technology, 23 (1), pp. 67-71. Springer. DOI: 10.1007/s12217-010-9234-5 ISSN 0938-0108 (online), 1875-0494 (Print)

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Official URL: http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s12217-010-9234-5

Abstract

In order to enable kinetic online measurements in cell cultures during exposure to altered gravitational stimulation a new device has been constructed. The analysis principle is based on photon counting with a photomultiplier tube (PMT). The system can work in a rotating mode (clinostat principle) as well as in 1g conditions. Biological verification was successfully performed with a Luminol-based luminescence measurement of the immune reaction of mammal macrophages. An identical methodical approach is foreseen for an ISS experiment (TRIPLE LUX). Alteration of the rotation speed of the PMT clinostat (60 and 2 rotations per minute – rpm) resulted in a speed-dependent decrease of the luminescent signal, contributing to the current discussion whether and how fast rotation of a sample around one axis perpendicular to the direction of the g-vector provides the condition of functional weightlessness or omnilateral mechano-(gravi-) stimulation.

Item URL in elib:https://elib.dlr.de/63420/
Document Type:Article
Additional Information:Published online: 15.09.2010
Title:PMT (Photomultiplier) Clinostat
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Horn, AstridGerman Aerospace Center, Institute of Aerospace Medicine, Biomedical Science Support Center, Cologne, Germany and Otto-von-Guericke University Magdeburg, Institute of Mechanical Engineering and EADS Astrium GmbH, Friedrichshafen, GermanyUNSPECIFIED
Ullrich, OliverUniversity of Zurich, Institute for Anatomy, Zürich, Switzerland and Otto-von-Guericke University Magdeburg, Institute of Mechanical Engineering, Magdeburg, GermanyUNSPECIFIED
Huber, KathrinUniversity of Zurich, Institute for Anatomy, Zürich, Switzerland and Otto-von-Guericke University Magdeburg, Institute of Mechanical Engineering, Magdeburg, GermanyUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Center, Institute of Aerospace Medicine, Biomedical Science Support Center, Cologne, GermanyUNSPECIFIED
Date:1 January 2011
Journal or Publication Title:Microgravity Science and Technology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:23
DOI :10.1007/s12217-010-9234-5
Page Range:pp. 67-71
Publisher:Springer
ISSN:0938-0108 (online), 1875-0494 (Print)
Status:Published
Keywords:Clinostat, Luminescence measurement, Oxidative burst, TRIPLE LUX
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Biowissenschaftliche Nutzerunterstützung (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Science Support Center
Deposited By: Lütz, Gertrud
Deposited On:08 Mar 2010 09:56
Last Modified:26 Mar 2013 13:15

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