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Bauermeister, Anja und Bentchikou, Esma und Moeller, Ralf und Rettberg, Petra (2009) Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation. Archives of Microbiology, 191, Seiten 913-918. Springer. doi: 10.1007/s00203-009-0522-7. ISSN 0302-8933 (Print) 1432-072X (Online).
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Kurzfassung
To study the role of different DNA repair genes in the resistance of Deinococcus radiodurans to mono- and polychromatic UV radiation, wild-type strain and knockout mutants in RecA, PprA, and IrrE of D. radiodurans were irradiated with UV-C (254 nm), UV-(A + B) (280–400 nm) and UV-A (315–400 nm) radiation, and survival was monitored. The strain deficient in recA was highly sensitive to UV-C radiation compared to the wild-type, but showed no loss of resistance against irradiation with UV-(A + B) and UV-A, while pprA and irrE-deficient strains exhibited elevated sensitivity to UV-A and UV-(A + B) radiation. These results suggest that the repair of DNA double-strand breaks is essential after treatment with highly energetic UV-C radiation, whereas protection from oxidative stress may play a greater role in resistance to environmentally relevant UV radiation.
| elib-URL des Eintrags: | https://elib.dlr.de/60769/ | ||||||||||||||||||||
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| Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||
| Titel: | Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation | ||||||||||||||||||||
| Autoren: |
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| Datum: | 2009 | ||||||||||||||||||||
| Erschienen in: | Archives of Microbiology | ||||||||||||||||||||
| Referierte Publikation: | Ja | ||||||||||||||||||||
| Open Access: | Nein | ||||||||||||||||||||
| Gold Open Access: | Nein | ||||||||||||||||||||
| In SCOPUS: | Ja | ||||||||||||||||||||
| In ISI Web of Science: | Ja | ||||||||||||||||||||
| Band: | 191 | ||||||||||||||||||||
| DOI: | 10.1007/s00203-009-0522-7 | ||||||||||||||||||||
| Seitenbereich: | Seiten 913-918 | ||||||||||||||||||||
| Verlag: | Springer | ||||||||||||||||||||
| ISSN: | 0302-8933 (Print) 1432-072X (Online) | ||||||||||||||||||||
| Status: | veröffentlicht | ||||||||||||||||||||
| Stichwörter: | Deinococcus radiodurans, 254 nm UV-C, Environmental UV radiation, DNA repair | ||||||||||||||||||||
| HGF - Forschungsbereich: | Verkehr und Weltraum (alt) | ||||||||||||||||||||
| HGF - Programm: | Weltraum (alt) | ||||||||||||||||||||
| HGF - Programmthema: | W FR - Forschung unter Weltraumbedingungen (alt) | ||||||||||||||||||||
| DLR - Schwerpunkt: | Weltraum | ||||||||||||||||||||
| DLR - Forschungsgebiet: | W FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||
| DLR - Teilgebiet (Projekt, Vorhaben): | W - Vorhaben Strahlenbiologie (alt) | ||||||||||||||||||||
| Standort: | Köln-Porz | ||||||||||||||||||||
| Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie | ||||||||||||||||||||
| Hinterlegt von: | Kopp, Kerstin | ||||||||||||||||||||
| Hinterlegt am: | 01 Dez 2009 14:15 | ||||||||||||||||||||
| Letzte Änderung: | 06 Sep 2019 15:23 |
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