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Assessment of space environmental factors by cytotoxicity bioassays

Hellweg, Christine E. and Arenz, Andrea and Baumstark-Khan, Christa (2007) Assessment of space environmental factors by cytotoxicity bioassays. ACTA ASTRONAUTICA, 60 (4-7), pp. 525-533. Elsevier.

Full text not available from this repository.

Abstract

Cellular bioassays for detection of cyto- and genotoxicity are useful in the risk assessment of space environmental factors. Such bioassay systems have the potential complement the physical detector systems used in space, insofar as they yield intrinsically biologically weighted measures of cellular responses. The experiment Cellular Responses to Radiation in Space (CERASP) has been selected by NASA/ESA to be performed on the International Space Station. It will supply basic information on the cellular response to radiation applied in microgravity. One of the biological endpoints under investigation will be survival reflected by radiation-dependent reduction of constitutive expression of the enhanced variant of green fluorescent protein (EGFP), originally isolated from the bioluminescent jellyfish Aequorea victoria. In this ground based study, the usefulness of this approach in comparison to standard techniques (colony forming ability test, MTT test) is shown.

Item URL in elib:https://elib.dlr.de/48138/
Document Type:Article
Title:Assessment of space environmental factors by cytotoxicity bioassays
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hellweg, Christine E.UNSPECIFIEDUNSPECIFIED
Arenz, AndreaUNSPECIFIEDUNSPECIFIED
Baumstark-Khan, ChristaUNSPECIFIEDUNSPECIFIED
Date:2007
Journal or Publication Title:ACTA ASTRONAUTICA
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:60
Page Range:pp. 525-533
Publisher:Elsevier
Status:Published
Keywords:Space radiation, Mammalian cells, Green fluorescent protein, Gene expression, Bioassay, Genotoxicity
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:14 May 2007
Last Modified:27 Apr 2009 13:43

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