Hellweg, Christine E. and Arenz, Andrea and Baumstark-Khan, Christa (2007) Assessment of space environmental factors by cytotoxicity bioassays. ACTA ASTRONAUTICA, 60 (4-7), pp. 525-533. Elsevier.
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Abstract
Cellular bioassays for detection of cyto- and genotoxicity are useful in the risk assessment of space environmental factors. Such bioassay systems have the potential complement the physical detector systems used in space, insofar as they yield intrinsically biologically weighted measures of cellular responses. The experiment Cellular Responses to Radiation in Space (CERASP) has been selected by NASA/ESA to be performed on the International Space Station. It will supply basic information on the cellular response to radiation applied in microgravity. One of the biological endpoints under investigation will be survival reflected by radiation-dependent reduction of constitutive expression of the enhanced variant of green fluorescent protein (EGFP), originally isolated from the bioluminescent jellyfish Aequorea victoria. In this ground based study, the usefulness of this approach in comparison to standard techniques (colony forming ability test, MTT test) is shown.
Item URL in elib: | https://elib.dlr.de/48138/ | ||||||||||||||||
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Document Type: | Article | ||||||||||||||||
Title: | Assessment of space environmental factors by cytotoxicity bioassays | ||||||||||||||||
Authors: |
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Date: | 2007 | ||||||||||||||||
Journal or Publication Title: | ACTA ASTRONAUTICA | ||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||
Open Access: | No | ||||||||||||||||
Gold Open Access: | No | ||||||||||||||||
In SCOPUS: | No | ||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||
Volume: | 60 | ||||||||||||||||
Page Range: | pp. 525-533 | ||||||||||||||||
Publisher: | Elsevier | ||||||||||||||||
Status: | Published | ||||||||||||||||
Keywords: | Space radiation, Mammalian cells, Green fluorescent protein, Gene expression, Bioassay, Genotoxicity | ||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport (old) | ||||||||||||||||
HGF - Program: | Space (old) | ||||||||||||||||
HGF - Program Themes: | W FR - Forschung unter Weltraumbedingungen (old) | ||||||||||||||||
DLR - Research area: | Space | ||||||||||||||||
DLR - Program: | W FR - Forschung unter Weltraumbedingungen | ||||||||||||||||
DLR - Research theme (Project): | W - Vorhaben Strahlenbiologie (old) | ||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Radiation Biology | ||||||||||||||||
Deposited By: | Kopp, Kerstin | ||||||||||||||||
Deposited On: | 14 May 2007 | ||||||||||||||||
Last Modified: | 27 Apr 2009 13:43 |
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