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Cellular Monitoring of the Nuclear Factor κB Pathway for Assessment of Space Environmental Radiation

Baumstark-Khan, Christa and Hellweg, Christine E. and Arenz, Andrea and Meier, Matthias M. (2005) Cellular Monitoring of the Nuclear Factor κB Pathway for Assessment of Space Environmental Radiation. Radiation Research, 164, pp. 527-530. Radiation Research Society.

Full text not available from this repository.

Abstract

A screening assay for the detection of NF-κB-dependent gene induction using the destabilized variant of the reporter protein enhanced green fluorescent protein (d2EGFP) is used for assessing the biological effects of accelerated heavy ions as a model of space environmental radiation conditions. The time course of d2EGFP expression and therefore of activation of NF-κB-dependent gene expression was measured after treatment with TNFA or after heavy-ion exposure using flow cytometry. The reported experiments clearly show that accelerated argon ions (95 MeV/nucleon, LET 230 keV/µm) induce the NF-κB pathway at low particle densities (1–2 particle hits per nucleus), which result in as few as 5–50 induced DSBs per cell.

Item URL in elib:https://elib.dlr.de/47583/
Document Type:Article
Title:Cellular Monitoring of the Nuclear Factor κB Pathway for Assessment of Space Environmental Radiation
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Baumstark-Khan, ChristaUNSPECIFIEDUNSPECIFIED
Hellweg, Christine E.UNSPECIFIEDUNSPECIFIED
Arenz, AndreaUNSPECIFIEDUNSPECIFIED
Meier, Matthias M.UNSPECIFIEDUNSPECIFIED
Date:2005
Journal or Publication Title:Radiation Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:164
Page Range:pp. 527-530
Publisher:Radiation Research Society
Status:Published
Keywords:Space Environmental Radiation, NF-κB dependent gene expression, flow cytometry, particle hits
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:19 Mar 2007
Last Modified:27 Apr 2009 13:35

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