elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Mutation induction in mammalian cells by accelerated heavy ions

Rosendahl, Ilja M. and Baumstark-Khan, Christa and Rink, Hermann (2005) Mutation induction in mammalian cells by accelerated heavy ions. Advances in Space Research, 36, pp. 1701-1709. Elsevier.

Full text not available from this repository.

Abstract

The deleterious effects of accelerated heavy ions on living cells are of increasing importance for long duration human space flight activities. An important aspect of this field is attributed to the type and quality of biological damage induced by these densely ionizing particles. To address this aspect, cell inactivation and mutation induction at the HPRT locus (coding for hypoxanthine guanine phosphoribosyltransferase) was investigated in cultured V79 Chinese Hamster Cells irradiated with accelerated heavy ions (16-O, 40-Ca, 197-Au, and 238-U) and X-rays. Specific energies of the ions ranged from 1.9 to 69.7 MeV/u and corresponding LET values were between 62 and 15,580 keV µm<sup>-1</sup>. While inactivation cross-sections (σ<sub>i</sub>) rise over the whole LET range, mutation induction cross-sections (σ<sub>m</sub>) increase up to approximately 300 keV µm<sup>-1</sup> (O-ions) but decline with heavier ions and more extreme LET values. A similar behavior is seen with mutation frequency dependent on particle fluence. After irradiation with accelerated uranium ions (8.8 MeV/u, 15,580 keV µm<sup>-1</sup>) a significant decrease of mutation frequency was found with higher particle fluences (3 x 10<sup>6</sup> particles cm<sup>-2</sup>). Nearly no mutants were recovered with 8 x 10<sup>6</sup> particles cm<sup>-2</sup>.

Item URL in elib:https://elib.dlr.de/47427/
Document Type:Article
Title:Mutation induction in mammalian cells by accelerated heavy ions
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rosendahl, Ilja M.UNSPECIFIEDUNSPECIFIED
Baumstark-Khan, ChristaUNSPECIFIEDUNSPECIFIED
Rink, HermannExperimental Radiology and Radiation Biology, Radiological University Clinics, 53104 Bonn, GermanyUNSPECIFIED
Date:2005
Journal or Publication Title:Advances in Space Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:36
Page Range:pp. 1701-1709
Editors:
EditorsEmail
COSPAR, UNSPECIFIED
Publisher:Elsevier
Status:Published
Keywords:Space, Densely ionizing radiation, Cell inactivation, Mutation induction, HPRT gene locus
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:05 Mar 2007
Last Modified:27 Apr 2009 13:33

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.