Drummer, C. and Fiedler, F. (1) and Bub, A. (2) and Kleefeld, D. (2) and Dimitriades, E. (1) and Gerzer, R. and Forssmann, W.-G. (2) (1993) Development and Application of a Urodilatin (CDD/ANP-95-126)-specificRadioimmunoassay. Pflügers Archiv - European Journal of Physiology, 423, pp. 372-377. Springer International, Heidelberg.
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Abstract
Urodilatin, a renal natriuretic peptide that is analogue to circulating atrial natriuretic peptide, is measurable with a highly specific and sensitive radioimmunoassay. While most ANP antibodies cannot distinguish between urodilatin and other ANP analogues, the polyclonal urodilatin antibodyspecifically measures human urodilatin without anycross-reactivity to other ANP analogues. Urodilatin is not detected in blood from healthy volunteers nor from cardiac patients. Urinary urodilatin accounts for only a part of total urinary ANP immunoreactivity. Urodilatin excretion closely parallels sodium excretion in response to an acute volume load while changes inurinary immunoreactive ANP excretion do not reflect this renal response. We conclude that specific urodilatin assays are required to explore further the physiological role of the renal natriuretic peptide.
Item URL in elib: | https://elib.dlr.de/26874/ | ||||||||||||||||||||||||
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Document Type: | Article | ||||||||||||||||||||||||
Additional Information: | LIDO-Berichtsjahr=1993, pages=6, | ||||||||||||||||||||||||
Title: | Development and Application of a Urodilatin (CDD/ANP-95-126)-specificRadioimmunoassay | ||||||||||||||||||||||||
Authors: |
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Date: | 1993 | ||||||||||||||||||||||||
Journal or Publication Title: | Pflügers Archiv - European Journal of Physiology | ||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||
Open Access: | No | ||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||||||||||
Volume: | 423 | ||||||||||||||||||||||||
Page Range: | pp. 372-377 | ||||||||||||||||||||||||
Publisher: | Springer International, Heidelberg | ||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||
Keywords: | Atrial natriuretic peptide, kidney, renal natriuretic peptide, sodium excretion, urodilatin | ||||||||||||||||||||||||
HGF - Research field: | UNSPECIFIED | ||||||||||||||||||||||||
HGF - Program: | Space (old) | ||||||||||||||||||||||||
HGF - Program Themes: | W EO - Erdbeobachtung | ||||||||||||||||||||||||
DLR - Research area: | UNSPECIFIED | ||||||||||||||||||||||||
DLR - Program: | W EO - Erdbeobachtung | ||||||||||||||||||||||||
DLR - Research theme (Project): | UNSPECIFIED | ||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine | ||||||||||||||||||||||||
Deposited By: | DLR-Beauftragter, elib | ||||||||||||||||||||||||
Deposited On: | 02 Apr 2006 | ||||||||||||||||||||||||
Last Modified: | 27 Apr 2009 06:23 |
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