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Development and Application of a Urodilatin (CDD/ANP-95-126)-specificRadioimmunoassay

Drummer, C. and Fiedler, F. (1) and Bub, A. (2) and Kleefeld, D. (2) and Dimitriades, E. (1) and Gerzer, R. and Forssmann, W.-G. (2) (1993) Development and Application of a Urodilatin (CDD/ANP-95-126)-specificRadioimmunoassay. Pflügers Archiv - European Journal of Physiology, 423, pp. 372-377. Springer International, Heidelberg.

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Abstract

Urodilatin, a renal natriuretic peptide that is analogue to circulating atrial natriuretic peptide, is measurable with a highly specific and sensitive radioimmunoassay. While most ANP antibodies cannot distinguish between urodilatin and other ANP analogues, the polyclonal urodilatin antibodyspecifically measures human urodilatin without anycross-reactivity to other ANP analogues. Urodilatin is not detected in blood from healthy volunteers nor from cardiac patients. Urinary urodilatin accounts for only a part of total urinary ANP immunoreactivity. Urodilatin excretion closely parallels sodium excretion in response to an acute volume load while changes inurinary immunoreactive ANP excretion do not reflect this renal response. We conclude that specific urodilatin assays are required to explore further the physiological role of the renal natriuretic peptide.

Item URL in elib:https://elib.dlr.de/26874/
Document Type:Article
Additional Information: LIDO-Berichtsjahr=1993, pages=6,
Title:Development and Application of a Urodilatin (CDD/ANP-95-126)-specificRadioimmunoassay
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Drummer, C.UNSPECIFIEDUNSPECIFIED
Fiedler, F. (1)UNSPECIFIEDUNSPECIFIED
Bub, A. (2)UNSPECIFIEDUNSPECIFIED
Kleefeld, D. (2)UNSPECIFIEDUNSPECIFIED
Dimitriades, E. (1)UNSPECIFIEDUNSPECIFIED
Gerzer, R.UNSPECIFIEDUNSPECIFIED
Forssmann, W.-G. (2)UNSPECIFIEDUNSPECIFIED
Date:1993
Journal or Publication Title:Pflügers Archiv - European Journal of Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:423
Page Range:pp. 372-377
Publisher:Springer International, Heidelberg
Status:Published
Keywords:Atrial natriuretic peptide, kidney, renal natriuretic peptide, sodium excretion, urodilatin
HGF - Research field:UNSPECIFIED
HGF - Program:Space (old)
HGF - Program Themes:W EO - Erdbeobachtung
DLR - Research area:UNSPECIFIED
DLR - Program:W EO - Erdbeobachtung
DLR - Research theme (Project):UNSPECIFIED
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: DLR-Beauftragter, elib
Deposited On:02 Apr 2006
Last Modified:27 Apr 2009 06:23

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