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Influence of the cGMP Analog 8-PCPT-cGMP on Agonist-Induced Increasesin Cytosolic Ionized Ca2+ and on Aggregation of Human Platelets

Menshikov, M. Y. (1) and Ivanova, Krassimira and Schaefer, M. (1) and Drummer, C. and Gerzer, R. (1993) Influence of the cGMP Analog 8-PCPT-cGMP on Agonist-Induced Increasesin Cytosolic Ionized Ca2+ and on Aggregation of Human Platelets. European Journal of Pharmacology - Molecular Pharmacology Section, 245, pp. 281-284. Elsevier Science Publishers B.V..

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Abstract

The present study was undertaken to compare inhibitory effects of the cGMP analog 8-(4-chlorophenylthio)guanosine 3`.5`-cyclic monophosphate (8-PCPT-cGMP) on increases in cytosolic ionized Ca2+ and on aggregation in human platelets induced via diverse agonists. Fura-2-loaded and gel-filtered platelets were stimulated by either ADP, thrombin, or collagen, respectively. The cGMP analog induced a concentration-dependent inhibition of cytosolic ionized Ca2+ increases and of aggregation to all agonist investigated with half-maximal inhibiting effects of approximately 100 nM. The data obtained suggest that both platelet Ca2+ exchange and aggregation have a similar sensitivity to the cGMP analog. In accordance with previously found significant differences between the potencies of nitric oxide (NO)-generating substances to inhibit increases in cytosolic ionized Ca2+ and aggregation, it appears that the anti- platelet effects of NO-releasing agents could only partially be explained by the elevation of cGMP levels.

Item URL in elib:https://elib.dlr.de/26870/
Document Type:Article
Additional Information: LIDO-Berichtsjahr=1993, pages=4,
Title:Influence of the cGMP Analog 8-PCPT-cGMP on Agonist-Induced Increasesin Cytosolic Ionized Ca2+ and on Aggregation of Human Platelets
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Menshikov, M. Y. (1)UNSPECIFIEDUNSPECIFIED
Ivanova, KrassimiraUNSPECIFIEDUNSPECIFIED
Schaefer, M. (1)UNSPECIFIEDUNSPECIFIED
Drummer, C.UNSPECIFIEDUNSPECIFIED
Gerzer, R.UNSPECIFIEDUNSPECIFIED
Date:1993
Journal or Publication Title:European Journal of Pharmacology - Molecular Pharmacology Section
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:No
In ISI Web of Science:Yes
Volume:245
Page Range:pp. 281-284
Publisher:Elsevier Science Publishers B.V.
Status:Published
Keywords:cGMP analog, Ca2+, platelet aggregation, nitric oxide (NO)
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W - no assignment
DLR - Research area:Space
DLR - Program:W - no assignment
DLR - Research theme (Project):W - no assignment (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: DLR-Beauftragter, elib
Deposited On:02 Apr 2006
Last Modified:11 Jul 2011 13:44

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