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Reduced Natriuresis During Weightlessness

Drummer, C. and Heer, M. and Dressendörfer, R. A. (1), Strasburger, C. J. (1), and Gerzer, R. (1993) Reduced Natriuresis During Weightlessness. The Clinical Investigator, 71. Springer International, Heidelberg.

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The kidney response to weightlessness was measured in one volunteer during a 1-week space mission. Shortly after entering microgravity and later during the mission, consecutive urine samplingperiods were monitored, covering in total about 50% of the inflight time. Preflight references were a sequence of ground-based experiments, which evaluated body fluid metabolism with different degrees of standardization. Additional variables, such as circadian rhythms and cortisol-associated stress, were also monitored. In contrast to current hypotheses, the volunteer showed a pronounced reduction in natriuresis and diuresis during the entire space flight,despite a considerable weight loss. For the first time, the urinary excretion of the renal natriuretic peptide urodilatin was also measured. Both, during the preflight experiments and during weightlessness, close correlations between urodilatin excretion and sodium excretion were observed. However, the correlation between natriuresis and urodilatin excretion was considerably altered during weightlessness. We conclude that the loss of body weight during spacespace flight is not related to an increased renal fluid loss and thaturodilatin might counteract the decrease in renal excretion observed in weightlessness.

Item URL in elib:https://elib.dlr.de/26866/
Document Type:Article
Additional Information: LIDO-Berichtsjahr=1993, pages=9,
Title:Reduced Natriuresis During Weightlessness
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Dressendörfer, R. A. (1), Strasburger, C. J. (1), UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Journal or Publication Title:The Clinical Investigator
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Publisher:Springer International, Heidelberg
Keywords:Body fluid regulation, circadian rhythm, natriuresis, natriuretic peptide, space flight, urodilatin
HGF - Research field:UNSPECIFIED
HGF - Program:Space (old)
HGF - Program Themes:W EO - Erdbeobachtung
DLR - Research area:UNSPECIFIED
DLR - Program:W EO - Erdbeobachtung
DLR - Research theme (Project):UNSPECIFIED
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: DLR-Beauftragter, elib
Deposited On:02 Apr 2006
Last Modified:27 Apr 2009 06:22

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