elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Pulmonary Responses to Lower Body Negative Pressure and Fluid Loading During Head-Down Tilt Bedrest

Hillebrecht, A. (1) and Schulz, H. (1) and Meyer, M. (1) and Baisch, F. and Beck, L. and Blomqvist, C. G (2) (1992) Pulmonary Responses to Lower Body Negative Pressure and Fluid Loading During Head-Down Tilt Bedrest. Acta Physiologica Astronautica, S604, pp. 35-42. Blackwell Scientific Publications, Oxford, England.

Full text not available from this repository.

Abstract

Exposure to microgravity redistributes body fluids with important secondary effects on cardiovascular function. We tested the hypothesis that the fluid shifts also affect pulmonary gas exchange. Microgravity was simulated in six male volunteers by a 10-day period of bedrest at 6 degrees head-down tilt (HDT). Lower body negative pressure (LBNP) and intravenous saline loading superimposed acute changes in fluid distribution on the prolonged effects of HDT. HDT produced relative dehydration and hypovolemia with decreased pulmonary blood flow and diffusing capacity. Before bedrest, pulmonary blood flow decreased by 24% during LBNP and diffusing capacity by 7%, while functional residual capacity increased by 14% (p<0.05). Intravenous saline loading caused a 24% increase in pulmonary blood-flow (p<0.05). Functional residual capacity decreasedby 10% and diffusing capacity by 6% (p<0.05). Lung tissue volume did not change significantly. Head-down tilt had only minor effects on the responses to LBNP and saline loading. We conclude that LBNP and intravenous saline loading produce major changes in pulmonary blood flow and minor effects on pulmonary gas exchange, and that the response to acute changes in fluid distribution is not significantly altered during simulated microgravity.

Item URL in elib:https://elib.dlr.de/26764/
Document Type:Article
Additional Information: LIDO-Berichtsjahr=1993, pages=8,
Title:Pulmonary Responses to Lower Body Negative Pressure and Fluid Loading During Head-Down Tilt Bedrest
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hillebrecht, A. (1)UNSPECIFIEDUNSPECIFIED
Schulz, H. (1)UNSPECIFIEDUNSPECIFIED
Meyer, M. (1)UNSPECIFIEDUNSPECIFIED
Baisch, F.UNSPECIFIEDUNSPECIFIED
Beck, L.UNSPECIFIEDUNSPECIFIED
Blomqvist, C. G (2)UNSPECIFIEDUNSPECIFIED
Date:1992
Journal or Publication Title:Acta Physiologica Astronautica
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Volume:S604
Page Range:pp. 35-42
Publisher:Blackwell Scientific Publications, Oxford, England
Series Name:144
Status:Published
Keywords:inert gas rebreathing, intravenous saline loading, microgravity, pulmonary gas exchange
HGF - Research field:UNSPECIFIED
HGF - Program:other
HGF - Program Themes:other
DLR - Research area:UNSPECIFIED
DLR - Program:no assignment
DLR - Research theme (Project):UNSPECIFIED
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: DLR-Beauftragter, elib
Deposited On:02 Apr 2006
Last Modified:27 Apr 2009 06:20

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.