Gaffney, F.A. and Buckey, J.C. and Lane, L.D. and Hillebrecht, A. and Schulz, H. and Meyer, M. and Baisch, F. and Beck, L. and Heer, M. and Maaß, H. and Arbeille, P. and Patat, F. and Blomqvist, C. G. (1992) The Effects of a 10-Day Period of Head-Down Tilt on the Cardiovascular Responses to Intravenous Saline Loading. Acta Physiologica Scandinavica, S604, pp. 121-130.
Full text not available from this repository.
Abstract
We tested the hypothesis that adaptation to microgravity, simulated by a 10-day period of head-down tilt (HDT), alters the responses to an intravenous fluid load by causing a larger fraction of the infused volume to be retained and magnifying the acute hemodynamic effects. HDT caused a significant (p<0.01) decrease in blood volume (-0.72 liters) and weight (-1.6 kg). Rapid infusion (22 ml/kg over 20 min.) of isotonic saline before, during, and after HDT produced a transient blood volume expansion with 18% of the infusate retained intravascularly after 2 hours. HDT had no effect on this response. Control hemodynamics were significantly different with lower cardiac output and higher total peripheral resistance (TPR) during and after HDT. Saline caused significant increases in cardiac output, heart rate, and stroke volume and a decrease in TPR. The magnitude and time course of these changes were not altered by HDT. The results refute the hypothesis and suggest that during HDT new set points or operating points were established for the control of intravascular volume and hemodynamic state.
Item URL in elib: | https://elib.dlr.de/26756/ | ||||||||||||||||||||||||||||||||||||||||||
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Document Type: | Article | ||||||||||||||||||||||||||||||||||||||||||
Additional Information: | LIDO-Berichtsjahr=1993, | ||||||||||||||||||||||||||||||||||||||||||
Title: | The Effects of a 10-Day Period of Head-Down Tilt on the Cardiovascular Responses to Intravenous Saline Loading | ||||||||||||||||||||||||||||||||||||||||||
Authors: |
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Date: | 1992 | ||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Acta Physiologica Scandinavica | ||||||||||||||||||||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||||||||||||||||||||
Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||||||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||||||||||||||||||||||||||||
Volume: | S604 | ||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 121-130 | ||||||||||||||||||||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||||||||||||||||||||
Keywords: | Microgravity, Systemic Hemodynamics, Volumeload | ||||||||||||||||||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport (old) | ||||||||||||||||||||||||||||||||||||||||||
HGF - Program: | other | ||||||||||||||||||||||||||||||||||||||||||
HGF - Program Themes: | other | ||||||||||||||||||||||||||||||||||||||||||
DLR - Research area: | Space | ||||||||||||||||||||||||||||||||||||||||||
DLR - Program: | no assignment | ||||||||||||||||||||||||||||||||||||||||||
DLR - Research theme (Project): | UNSPECIFIED | ||||||||||||||||||||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine | ||||||||||||||||||||||||||||||||||||||||||
Deposited By: | DLR-Beauftragter, elib | ||||||||||||||||||||||||||||||||||||||||||
Deposited On: | 02 Apr 2006 | ||||||||||||||||||||||||||||||||||||||||||
Last Modified: | 27 Apr 2009 06:20 |
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