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Effect of Head-Down Tilt Bedrest (10 Days) on Lymphocyte Reactivity

Gmünder, F. K. and Baisch, F. and Bechler, B. and Cogoli, A. and Cogoli, M. and Joller, P. W. and Maaß, H. and Müller, J. and Ziegler, W. H. (1992) Effect of Head-Down Tilt Bedrest (10 Days) on Lymphocyte Reactivity. Acta Physiologica Scandinavica, S604, pp. 131-141.

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Immunological responses of six healthy males to 10 days of headdown tilt bedrest (HDT) were assessed. Lymphocyte responsiveness was severely reduced immediately before, during, and immediately after the HDT, even though the lymphocyte numbers did not change. By contrast, delayed-type hypersensitivity was not affected. No dramatic changes were found in WBC counts and lymphocyte subpopulations, with the only exception of natural killer (NK) cells which transiently decreased immediatley after HDT. Plasma cortisol levels were elevated above normal immediately before and during the HDT. The data suggest that the mitogenic response of lymphocytes was affected by psychological and fluid shift stress. These results are compared with data obtained during and after spaceflight. We conclude that the stress of HDT induces changes in immunological responsiveness that are strikingly similar to those arising from the stress of spaceflight.

Item URL in elib:https://elib.dlr.de/26754/
Document Type:Article
Additional Information: LIDO-Berichtsjahr=1992,
Title:Effect of Head-Down Tilt Bedrest (10 Days) on Lymphocyte Reactivity
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Gmünder, F. K.Institute of Biotechnology, ETH, Hönggerberg, SchweizUNSPECIFIEDUNSPECIFIED
Bechler, B.Institute of Biotechnology, ETH, Hönggerberg, SchweizUNSPECIFIEDUNSPECIFIED
Cogoli, A.Institute of Biotechnology, ETH, Hönggerberg, SchweizUNSPECIFIEDUNSPECIFIED
Cogoli, M.Institute of Biotechnology, ETH, Hönggerberg, SchweizUNSPECIFIEDUNSPECIFIED
Joller, P. W.ANAWA Laboratories, Wengen, SchweizUNSPECIFIEDUNSPECIFIED
Müller, J.University Hospital, Zürich, SchweizUNSPECIFIEDUNSPECIFIED
Ziegler, W. H.University Hospital, Zürich, SchweizUNSPECIFIEDUNSPECIFIED
Journal or Publication Title:Acta Physiologica Scandinavica
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 131-141
Keywords:cortisol, delayed-type hypersensitivity, epinephrine, immunity, lymphocyte activation, norepinephrine, skin test, spaceflight stress, subpopulations
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:other
HGF - Program Themes:other
DLR - Research area:Space
DLR - Program:no assignment
DLR - Research theme (Project):UNSPECIFIED
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: DLR-Beauftragter, elib
Deposited On:02 Apr 2006
Last Modified:27 Apr 2009 06:19

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