Astrocyte reactivity can be modulated by altered gravity

Lichterfeld, Yannick and Schunk, Sarah and Kalinski, Laura and Schmakeit, Theresa and Meerholz, Zoe and Sturm, Maximilan and Lau, Patrick and Feles, Sebastian and Frett, Timo and Hemmersbach, Ruth and Liemersdorf, Christian (2023) Astrocyte reactivity can be modulated by altered gravity. 61. Jahrestagung der DGLRM e.V., 2023-10-19 - 2023-10-21, Köln, Deutschland.

PDF
1MB

Abstract

Astrocytes are the most prevalent type of glial cells in the brain. These cells show a high impact on the regulation of neuronal signaling and play a key role in neuronal regeneration. The regeneration of neuronal projections is modulated by astrocytes that change into a reactive state (reactive astrogliosis). This mechanism of astrocyte reactivity on the one hand prevents the proliferation of inflammatory signaling and infection, but on the other hand inhibits neuronal regeneration through glial scarring.

Item URL in elib:

https://elib.dlr.de/210951/

Document Type:

Conference or Workshop Item (Poster)

Title:

Astrocyte reactivity can be modulated by altered gravity

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
Lichterfeld, Yannick	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0001-8755-9920	UNSPECIFIED
Schunk, Sarah	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0002-9968-6123	UNSPECIFIED
Kalinski, Laura	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0009-0009-4447-3460	UNSPECIFIED
Schmakeit, Theresa	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	UNSPECIFIED	UNSPECIFIED
Meerholz, Zoe	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	UNSPECIFIED	UNSPECIFIED
Sturm, Maximilan	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	UNSPECIFIED	UNSPECIFIED
Lau, Patrick	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0002-7290-5875	UNSPECIFIED
Feles, Sebastian	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0002-5008-6290	UNSPECIFIED
Frett, Timo	german aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germany	https://orcid.org/0000-0002-5572-1177	UNSPECIFIED
Hemmersbach, Ruth	German Aerospace Center (DLR), Institute of Aerospace Medicine, Department of Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0001-5308-6715	UNSPECIFIED
Liemersdorf, Christian	German Aerospace Center (DLR), Institute of Aerospace Medicine, Department of Applied Aerospace Biology, Cologne, Germanyy	https://orcid.org/0000-0001-8407-5226	UNSPECIFIED

Date:

19 October 2023

Refereed publication:

Yes

Open Access:

Yes

Gold Open Access:

In SCOPUS:

In ISI Web of Science:

Status:

Published

Keywords:

Hypergravity, Simulated Microgravity, Astrocytes, glial cells, neuronal regeneration

Event Title:

61. Jahrestagung der DGLRM e.V.

Event Location:

Köln, Deutschland

Event Type:

national Conference

Event Start Date:

19 October 2023

Event End Date:

21 October 2023

HGF - Research field:

Aeronautics, Space and Transport

HGF - Program:

Space

HGF - Program Themes:

Research under Space Conditions

DLR - Research area:

Raumfahrt

DLR - Program:

R FR - Research under Space Conditions

DLR - Research theme (Project):

R - Gravisensorics

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine > Gravitational Biology

Deposited By:

Chiodo, Annette

Deposited On:

14 Jan 2025 13:30

Last Modified:

15 Jan 2025 09:02

Repository Staff Only: item control page