Application of hyper-g as a countermeasure option for immune deficiencies

Moser, Dominique and Biere, Katharina and Liemersdorf, Christian and Hemmersbach, Ruth and Choukér, Alexander (2023) Application of hyper-g as a countermeasure option for immune deficiencies. ESA CORA Ground Based Facilities Symposium 2023, 2023-12-05, ESTEC, The Netherlands.

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Abstract

Microgravity (ug) is regarded as one of the major stressors in space causing immune cell dysregulations. Artificial gravity (AG) encompasses both the restoration of 1g in ug as well as the induction of hypergravity in order to counteract ug-induced deconditioning in space. This approach has already shown efficiency as a countermeasure option for ug-related musculoskeletal and cardiovascular deconditioning and as “gravitational therapy” on Earth. However, the impact on the human immune system was yet only sparsely explored. In a shorttime in vitro approach it was tested whether “mild” hypergravity (2.8g) may counteract simulated (s-)ug-induced dysregulations of monocytes and T cells.

Item URL in elib:

https://elib.dlr.de/210895/

Document Type:

Conference or Workshop Item (Speech)

Title:

Application of hyper-g as a countermeasure option for immune deficiencies

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
Moser, Dominique	Ludwig-Maximilian-University (LMU) Hospital, Department of Anesthesiology, Laboratory of Translational Research, Munich, Germany	UNSPECIFIED	UNSPECIFIED
Biere, Katharina	Ludwig-Maximilian-University (LMU) Hospital, Department of Anesthesiology, Laboratory of Translational Research, Munich, Germany	UNSPECIFIED	UNSPECIFIED
Liemersdorf, Christian	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0001-8407-5226	UNSPECIFIED
Hemmersbach, Ruth	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0001-5308-6715	UNSPECIFIED
Choukér, Alexander	Ludwig-Maximilian-University (LMU) Hospital, Department of Anesthesiology, Laboratory of Translational Research, Munich, Germany	https://orcid.org/0000-0002-0133-4104	UNSPECIFIED

Date:

5 December 2023

Refereed publication:

Open Access:

Gold Open Access:

In SCOPUS:

In ISI Web of Science:

Status:

Published

Keywords:

Artificial gravity (AG), hypergravity, cardiovascular, musculoskeletal, deconditioning, simulated microgravity, Microgravity (ug)

Event Title:

ESA CORA Ground Based Facilities Symposium 2023

Event Location:

ESTEC, The Netherlands

Event Type:

international Conference

Event Date:

5 December 2023

Organizer:

ESA European Space Agency

HGF - Research field:

Aeronautics, Space and Transport

HGF - Program:

Space

HGF - Program Themes:

Research under Space Conditions

DLR - Research area:

Raumfahrt

DLR - Program:

R FR - Research under Space Conditions

DLR - Research theme (Project):

R - Gravisensorics

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine > Gravitational Biology

Deposited By:

Chiodo, Annette

Deposited On:

14 Jan 2025 13:16

Last Modified:

14 Jan 2025 13:16

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