The LIFT module: A multi-cell type platform for biochemical analyses under altered gravity conditions

Schunk, Sarah and Holbeck, Ilse Marie and Prior, Robert and Lichterfeld, Yannick and Feles, Sebastian and Schmakeit, Theresa and Meerholz, Zoe and Hemmersbach, Ruth and Busskamp, Volker and Liemersdorf, Christian (2024) The LIFT module: A multi-cell type platform for biochemical analyses under altered gravity conditions. 28th ELGRA Biennial Symposium and General Assembly, 2024-09-03 - 2024-09-06, Liverpool, GB.

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Abstract

The Laminar Inflight Fixation Technology (LIFT) module is a frequent-flyer payload designed to enable a fast and reliable chemical fixation of biological samples during different phases of a sounding rocket flight for subsequent biochemical analysis. The modularity and reliability of the LIFT module were already proven during the rocket campaigns MAPHEUS-13 and -14 by chemically fixating different neuronal cell types, i.e. human-induced pluripotent stem cell (hiPCS) derived motor neurons and primary murine cortical astrocytes. Analyzing the effects of microgravity on these neuronal cell types will further our understanding of microgravity exposure on the brain and central nervous system of astronauts on a cellular level.

Item URL in elib:

https://elib.dlr.de/210135/

Document Type:

Conference or Workshop Item (Poster)

Title:

The LIFT module: A multi-cell type platform for biochemical analyses under altered gravity conditions

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
Schunk, Sarah	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0002-9968-6123	UNSPECIFIED
Holbeck, Ilse Marie	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0009-0003-2228-9140	UNSPECIFIED
Prior, Robert	University Clinic of Bonn, Department of Ophthalmology, Bonn, Germany	UNSPECIFIED	UNSPECIFIED
Lichterfeld, Yannick	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	UNSPECIFIED	UNSPECIFIED
Feles, Sebastian	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	https://orcid.org/0000-0002-5008-6290	UNSPECIFIED
Schmakeit, Theresa	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	UNSPECIFIED	UNSPECIFIED
Meerholz, Zoe	German Aerospace Centre (DLR), Institute of Aerospace Medicine, Applied Aerospace Biology, Cologne, Germany	UNSPECIFIED	UNSPECIFIED
Hemmersbach, Ruth	German Aerospace Center (DLR), Institute of Aerospace Medicine, Department of Applied Aerospace Biology, 51147 Cologne, Germany	https://orcid.org/0000-0001-5308-6715	UNSPECIFIED
Busskamp, Volker	University of Bonn, Dep. of Ophthalmology	UNSPECIFIED	UNSPECIFIED
Liemersdorf, Christian	German Aerospace Center (DLR), Institute of Aerospace Medicine, Department of Applied Aerospace Biology, 51147 Cologne, Germanyy	https://orcid.org/0000-0001-8407-5226	UNSPECIFIED

Date:

4 September 2024

Refereed publication:

Open Access:

Yes

Gold Open Access:

In SCOPUS:

In ISI Web of Science:

Status:

Published

Keywords:

Laminar Inflight Fixation Technology (LIFT), chemical fixation, sounding rocket, MAPHEUS, stem cells, neurons, astrocytes, microgravity

Event Title:

28th ELGRA Biennial Symposium and General Assembly

Event Location:

Liverpool, GB

Event Type:

international Conference

Event Start Date:

3 September 2024

Event End Date:

6 September 2024

Organizer:

ELGRA (European Low Gravity Research Association)

HGF - Research field:

Aeronautics, Space and Transport

HGF - Program:

Space

HGF - Program Themes:

Research under Space Conditions

DLR - Research area:

Raumfahrt

DLR - Program:

R FR - Research under Space Conditions

DLR - Research theme (Project):

R - Gravisensorics

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine > Gravitational Biology

Deposited By:

Chiodo, Annette

Deposited On:

05 Dec 2024 10:06

Last Modified:

05 Dec 2024 10:06

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