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How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Willis, Craig R. G. and Calvaruso, Marco and Angeloni, Debora and Baatout, Sarah and Benchoua, Alexandra and Bereiter-Hahn, Juergen and Bottai, Daniele and Buchheim, Judith-Irina and Carnero-Diaz, Eugénie and Castiglioni, Sara and Cavalieri, Duccio and Ceccarelli, Gabriele and Chouker, Alexander and Cialdai, Francesca and Ciofani, Gianni and Coppola, Giuseppe and Cusella, Gabriella and Degl’Innocenti, Andrea and Desaphy, Jean-Francois and Frippiat, Jean-Pol and Gelinsky, Michael and Genchi, Giada and Grano, Maria and Grimm, Daniela and Guignandon, Alain and Herranz, Raúl and Hellweg, Christine Elisabeth and Iorio, Carlo Saverio and Karapantsios, Thodoris and van Loon, Jack and Lulli, Matteo and Maier, Jeanette and Malda, Jos and Mamaca, Emina and Morbidelli, Lucia and Osterman, Andreas and Ovsianikov, Aleksandr and Pampaloni, Francesco and Pavezlorie, Elizabeth and Pereda-Campos, Veronica and Przybyla, Cyrille and Rettberg, Petra and Rizzo, Angela Maria and Robson-Brown, Kate and Rossi, Leonardo and Russo, Giorgio and Salvetti, Alessandra and Risaliti, Chiara and Santucci, Daniela and Sperl, Matthias and Tabury, Kevin and Tavella, Sara and Thielemann, Christiane and Willaert, Ronnie and Monici, Monica and Szewczyk, Nathaniel J. (2024) How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? npj Microgravity, 10 (1), p. 50. Nature Publishing Group. doi: 10.1038/s41526-024-00395-3. ISSN 2373-8065.

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Official URL: https://dx.doi.org/10.1038/s41526-024-00395-3

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Item URL in elib:https://elib.dlr.de/207441/
Document Type:Article
Title:How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Willis, Craig R. G.School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, United KingdomUNSPECIFIEDUNSPECIFIED
Calvaruso, MarcoInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Cefalù, ItalyUNSPECIFIEDUNSPECIFIED
Angeloni, DeboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baatout, SarahUNSPECIFIEDhttps://orcid.org/0000-0001-8110-751XUNSPECIFIED
Benchoua, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bereiter-Hahn, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bottai, DanieleUNSPECIFIEDhttps://orcid.org/0000-0002-7951-9512UNSPECIFIED
Buchheim, Judith-IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carnero-Diaz, EugénieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castiglioni, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavalieri, DuccioUNSPECIFIEDhttps://orcid.org/0000-0001-6426-5719UNSPECIFIED
Ceccarelli, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chouker, AlexanderUNSPECIFIEDhttps://orcid.org/0000-0002-0133-4104UNSPECIFIED
Cialdai, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ciofani, GianniUNSPECIFIEDhttps://orcid.org/0000-0003-1192-3647UNSPECIFIED
Coppola, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cusella, GabriellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degl’Innocenti, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Desaphy, Jean-FrancoisUNSPECIFIEDhttps://orcid.org/0000-0001-8816-9369UNSPECIFIED
Frippiat, Jean-PolUNSPECIFIEDhttps://orcid.org/0000-0002-4027-6269UNSPECIFIED
Gelinsky, MichaelUNSPECIFIEDhttps://orcid.org/0000-0001-9075-5121UNSPECIFIED
Genchi, GiadaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grano, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimm, DanielaUNSPECIFIEDhttps://orcid.org/0000-0002-4991-3105UNSPECIFIED
Guignandon, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herranz, RaúlUNSPECIFIEDhttps://orcid.org/0000-0002-0246-9449UNSPECIFIED
Hellweg, Christine ElisabethUNSPECIFIEDhttps://orcid.org/0000-0002-2223-3580UNSPECIFIED
Iorio, Carlo SaverioUNSPECIFIEDhttps://orcid.org/0000-0003-0952-0064UNSPECIFIED
Karapantsios, ThodorisUNSPECIFIEDhttps://orcid.org/0000-0001-6641-3359UNSPECIFIED
van Loon, JackUNSPECIFIEDhttps://orcid.org/0000-0001-9051-6016UNSPECIFIED
Lulli, MatteoUNSPECIFIEDhttps://orcid.org/0000-0002-8528-4094UNSPECIFIED
Maier, JeanetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malda, JosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mamaca, EminaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morbidelli, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osterman, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ovsianikov, AleksandrUNSPECIFIEDhttps://orcid.org/0000-0001-5846-0198UNSPECIFIED
Pampaloni, FrancescoUNSPECIFIEDhttps://orcid.org/0000-0003-4357-7320UNSPECIFIED
Pavezlorie, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pereda-Campos, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Przybyla, CyrilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rettberg, PetraUNSPECIFIEDhttps://orcid.org/0000-0003-4439-2395UNSPECIFIED
Rizzo, Angela MariaUNSPECIFIEDhttps://orcid.org/0000-0002-8582-0432UNSPECIFIED
Robson-Brown, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossi, LeonardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russo, GiorgioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvetti, AlessandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Risaliti, ChiaraUNSPECIFIEDhttps://orcid.org/0000-0003-1695-0548UNSPECIFIED
Santucci, DanielaUNSPECIFIEDhttps://orcid.org/0000-0002-4619-1290UNSPECIFIED
Sperl, MatthiasUNSPECIFIEDhttps://orcid.org/0000-0001-9525-0368169749417
Tabury, KevinUNSPECIFIEDhttps://orcid.org/0000-0002-8004-3718UNSPECIFIED
Tavella, SaraUNSPECIFIEDhttps://orcid.org/0000-0003-1478-4910UNSPECIFIED
Thielemann, ChristianeUNSPECIFIEDhttps://orcid.org/0000-0002-9814-4744UNSPECIFIED
Willaert, RonnieUNSPECIFIEDhttps://orcid.org/0000-0002-5400-7019UNSPECIFIED
Monici, MonicaUNSPECIFIEDhttps://orcid.org/0000-0001-6678-9241UNSPECIFIED
Szewczyk, Nathaniel J.UNSPECIFIEDhttps://orcid.org/0000-0003-4425-9746UNSPECIFIED
Date:1 May 2024
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI:10.1038/s41526-024-00395-3
Page Range:p. 50
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:roadmap
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Model systems, R - radiation risks
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Physics in Space > Scientific Experiments MP
Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:17 Oct 2024 11:41
Last Modified:17 Oct 2024 11:41

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