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Copper stress response of aspergillus niger spores and the implications for antifungal surface functionalization

Koch, S.M. and Siems, K. and Schiele, A. and Müller, D.W. and Ahmed, A. and Brix, K. and Mücklich, F. and Kautenburger, R. and Moeller, R. (2024) Copper stress response of aspergillus niger spores and the implications for antifungal surface functionalization. In: DGHM & VAAM 2024 7th Joint Microbiology & Infection Conference. DGHM & VAAM 2024, 2024-06-02 - 2024-06-05, Würzburg, Deutschland.

Full text not available from this repository.

Official URL: https://dghm-vaam.de/fileadmin/media/dghm-vaam/2024/docs/DGHM_VAAM2024_Abstracts.pdf

Abstract

Microbial life has been an enduring presence in various environments, prompting research into understanding the interactions between microorganisms and antimicrobial agents. Not only in terrestrial settings but even in human spaceflight related environments, Aspergillus niger has been identified alongside Penicillium ssp. as predominant species in HEPA filters and dust within the international space station. As especially fungal contaminations could have detrimental effects on built materials and negatively affect not only the structural integrity of a confined built environment, but cause negative effects on human health, it underscores the need to understand especially fungal responses to stress. Within this study we particularly researched the fungal stress response from novel functionalized copper surfaces. This study delves into the interaction between A. niger and innovative antimicrobial surfaces, combining actively antimicrobial copper and copper-alloys with microtopographies through Ultrashort pulses Direct Laser Interference Patterning (USP-DLIP). The preliminary findings of contact – killing assays using spores from a wildtype and melanin deficient mutant strain, reveal an unexpected heterogeneity in A. niger spore germination responses to copper stress, shedding light on the sophisticated regulation of copper homeostasis by this fungus. The results of those assays were further investigated using varied microscopy methods (Fluorescence and SEM) and will undergo detailed RNA profile analyses to discern the molecular mechanisms underlying any observed damage, providing valuable insights into the intricacies of A. niger's response to copperinduced stress. Understanding how A. niger reacts to copper stress is crucial for developing effective antimicrobial strategies with broader applications, addressing fungal contamination challenges across diverse settings.

Item URL in elib:https://elib.dlr.de/204873/
Document Type:Conference or Workshop Item (Poster)
Title:Copper stress response of aspergillus niger spores and the implications for antifungal surface functionalization
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Koch, S.M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siems, K.UNSPECIFIEDhttps://orcid.org/0000-0001-7349-0846UNSPECIFIED
Schiele, A.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Müller, D.W.Material Engineering Center Saarland (MECS), Department of Material Science of Engineering, Saarland, GermanyUNSPECIFIEDUNSPECIFIED
Ahmed, A.Material Engineering Center Saarland (MECS), Department of Material Science of Engineering, Saarland, GermanyUNSPECIFIEDUNSPECIFIED
Brix, K.Saarland University, Department of Inorganic Solid-State Chemistry, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Mücklich, F.Material Engineering Center Saarland (MECS), Department of Material Science of Engineering, Saarland, GermanyUNSPECIFIEDUNSPECIFIED
Kautenburger, R.Saarland University, Department of Inorganic Solid-State Chemistry, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Moeller, R.UNSPECIFIEDhttps://orcid.org/0000-0002-2371-0676UNSPECIFIED
Date:2 June 2024
Journal or Publication Title:DGHM & VAAM 2024 7th Joint Microbiology & Infection Conference
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Microbial life, Aspergillus niger, antimicrobial surfaces, copper stress
Event Title:DGHM & VAAM 2024
Event Location:Würzburg, Deutschland
Event Type:international Conference
Event Start Date:2 June 2024
Event End Date:5 June 2024
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project ISS LIFE 2.0
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:25 Jun 2024 10:40
Last Modified:25 Jun 2024 10:40

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