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How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Davis, Trent and Tabury, Kevin and Zhu, Shouan and Angeloni, Debora and Baatout, Sarah and Benchoua, Alexandra and Bereiter-Hahn, Juergen and Bottai, Daniele and Buchheim, Judith-Irina and Calvaruso, Marco and Carnero-Diaz, Eugénie and Castiglioni, Sara and Cavalieri, Duccio and Ceccarelli, Gabriele and Choukér, Alexander and Cialdai, Francesca and Ciofani, Gianni and Coppola, Giuseppe and Cusella, Gabriella and Degl’Innocenti, Andrea and Desaphy, Jean-Francois and Frippiat, Jean-Pol and Gelinsky, Michael and Genchi, Giada and Grano, Maria and Grimm, Daniela and Guignandon, Alain and Hahn, Christiane and Hatton, Jason and Herranz, Raúl and Hellweg, Christine Elisabeth and Iorio, Carlo Saverio and Karapantsios, Thodoris and van Loon, Jack J.W.A. and Lulli, Matteo and Maier, Jeanette and Malda, Jos and Mamaca, Emina and Morbidelli, Lucia and van Ombergen, Angelique and Osterman, Andreas and Ovsianikov, Aleksandr and Pampaloni, Francesco and Pavezlorie, Elizabeth and Pereda-Campos, Veronica and Przybyla, Cyrille and Puhl, Christopher and Rettberg, Petra and Rizzo, Angela Maria and Robson-Brown, Kate and Rossi, Leonardo and Russo, Giorgio and Salvetti, Alessandra and Santucci, Daniela and Sperl, Matthias and Tavella, Sara and Thielemann, Christiane and Willaert, Ronnie and Szewczyk, Nathaniel and Monici, Monica (2024) How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? npj Microgravity, 10 (1), p. 16. Nature Publishing Group. doi: 10.1038/s41526-024-00357-9. ISSN 2373-8065.

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Official URL: https://dx.doi.org/10.1038/s41526-024-00357-9

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Item URL in elib:https://elib.dlr.de/203294/
Document Type:Article
Title:How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Davis, TrentUNSPECIFIEDhttps://orcid.org/0000-0001-5704-0335UNSPECIFIED
Tabury, KevinUNSPECIFIEDhttps://orcid.org/0000-0002-8004-3718UNSPECIFIED
Zhu, ShouanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angeloni, DeboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baatout, SarahUNSPECIFIEDhttps://orcid.org/0000-0001-8110-751XUNSPECIFIED
Benchoua, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bereiter-Hahn, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bottai, DanieleUNSPECIFIEDhttps://orcid.org/0000-0002-7951-9512UNSPECIFIED
Buchheim, Judith-IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calvaruso, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carnero-Diaz, EugénieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castiglioni, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavalieri, DuccioUNSPECIFIEDhttps://orcid.org/0000-0001-6426-5719UNSPECIFIED
Ceccarelli, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choukér, AlexanderUNSPECIFIEDhttps://orcid.org/0000-0002-0133-4104UNSPECIFIED
Cialdai, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ciofani, GianniUNSPECIFIEDhttps://orcid.org/0000-0003-1192-3647UNSPECIFIED
Coppola, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cusella, GabriellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degl’Innocenti, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Desaphy, Jean-FrancoisUNSPECIFIEDhttps://orcid.org/0000-0001-8816-9369UNSPECIFIED
Frippiat, Jean-PolUNSPECIFIEDhttps://orcid.org/0000-0002-4027-6269UNSPECIFIED
Gelinsky, MichaelUNSPECIFIEDhttps://orcid.org/0000-0001-9075-5121UNSPECIFIED
Genchi, GiadaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grano, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimm, DanielaUNSPECIFIEDhttps://orcid.org/0000-0002-4991-3105UNSPECIFIED
Guignandon, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahn, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hatton, JasonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herranz, RaúlUNSPECIFIEDhttps://orcid.org/0000-0002-0246-9449UNSPECIFIED
Hellweg, Christine ElisabethUNSPECIFIEDhttps://orcid.org/0000-0002-2223-3580UNSPECIFIED
Iorio, Carlo SaverioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karapantsios, ThodorisUNSPECIFIEDhttps://orcid.org/0000-0001-6641-3359UNSPECIFIED
van Loon, Jack J.W.A.UNSPECIFIEDhttps://orcid.org/0000-0001-9051-6016UNSPECIFIED
Lulli, MatteoUNSPECIFIEDhttps://orcid.org/0000-0002-8528-4094UNSPECIFIED
Maier, JeanetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malda, JosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mamaca, EminaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morbidelli, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Ombergen, AngeliqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osterman, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ovsianikov, AleksandrUNSPECIFIEDhttps://orcid.org/0000-0001-5846-0198UNSPECIFIED
Pampaloni, FrancescoUNSPECIFIEDhttps://orcid.org/0000-0003-4357-7320UNSPECIFIED
Pavezlorie, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pereda-Campos, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Przybyla, CyrilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puhl, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rettberg, PetraUNSPECIFIEDhttps://orcid.org/0000-0003-4439-2395UNSPECIFIED
Rizzo, Angela MariaUNSPECIFIEDhttps://orcid.org/0000-0002-8582-0432UNSPECIFIED
Robson-Brown, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossi, LeonardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russo, GiorgioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvetti, AlessandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santucci, DanielaUNSPECIFIEDhttps://orcid.org/0000-0002-4619-1290UNSPECIFIED
Sperl, MatthiasUNSPECIFIEDhttps://orcid.org/0000-0001-9525-0368155862871
Tavella, SaraUNSPECIFIEDhttps://orcid.org/0000-0003-1478-4910UNSPECIFIED
Thielemann, ChristianeUNSPECIFIEDhttps://orcid.org/0000-0002-9814-4744UNSPECIFIED
Willaert, RonnieUNSPECIFIEDhttps://orcid.org/0000-0002-5400-7019UNSPECIFIED
Szewczyk, NathanielUNSPECIFIEDhttps://orcid.org/0000-0003-4425-9746UNSPECIFIED
Monici, MonicaUNSPECIFIEDhttps://orcid.org/0000-0001-6678-9241UNSPECIFIED
Date:10 February 2024
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI:10.1038/s41526-024-00357-9
Page Range:p. 16
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:Cell biology, Systems biology
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project ISS LIFE 2.0, R - RepairChoice
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Materials Physics in Space > Scientific Experiments MP
Deposited By: Kopp, Kerstin
Deposited On:20 Mar 2024 10:11
Last Modified:20 Mar 2024 16:37

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