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The impact of bed rest on human skeletal muscle metabolism

Eggelbusch, Moritz and Braeden, T. Charlton and Bosutti, Alessandra and Ganse, Bergita and Giakoumaki, Ifigeneia and Grootemaat, Anita E. and Hendrickse, Paul William and Jaspers, Yorrick and Kemp, Stephan and Kerkhoff, Tom J. and Noort, Wendy and van Weeghel, Michel and van der Wel, Nicole N. and Wesseling, Julia R. and Frings-Meuthen, Petra and Rittweger, Jörn and Mulder, Edwin and Jaspers, Richard and Degens, Hans and Wüst, Rob (2024) The impact of bed rest on human skeletal muscle metabolism. Cell Reports Medicine, 5 (1), p. 101372. Elsevier. doi: 10.1016/j.xcrm.2023.101372. ISSN 2666-3791.

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Official URL: https://doi.org/10.1016/j.xcrm.2023.101372

Abstract

itivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.

Item URL in elib:https://elib.dlr.de/203254/
Document Type:Article
Title:The impact of bed rest on human skeletal muscle metabolism
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Eggelbusch, MoritzVrije Universiteit AmsterdamUNSPECIFIEDUNSPECIFIED
Braeden, T. CharltonVrije Universiteit AmsterdamUNSPECIFIEDUNSPECIFIED
Bosutti, AlessandraDepartment of Life Sciences, University Triest, ItalienUNSPECIFIEDUNSPECIFIED
Ganse, BergitaSaarland University, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Giakoumaki, IfigeneiaManchester Metropolitan University, Manchester, UKUNSPECIFIEDUNSPECIFIED
Grootemaat, Anita E.Amsterdam University Medical CentersUNSPECIFIEDUNSPECIFIED
Hendrickse, Paul WilliamManchester Metropolitan UniversityUNSPECIFIEDUNSPECIFIED
Jaspers, YorrickAmsterdam University Medical CentersUNSPECIFIEDUNSPECIFIED
Kemp, StephanAmsterdam University Medical CentersUNSPECIFIEDUNSPECIFIED
Kerkhoff, Tom J.Vrije Universiteit AmsterdamUNSPECIFIEDUNSPECIFIED
Noort, WendyVrije Universiteit AmsterdamUNSPECIFIEDUNSPECIFIED
van Weeghel, MichelAmsterdam University Medical CentersUNSPECIFIEDUNSPECIFIED
van der Wel, Nicole N.Amsterdam University Medical CentersUNSPECIFIEDUNSPECIFIED
Wesseling, Julia R.Vrije Universiteit AmsterdamUNSPECIFIEDUNSPECIFIED
Frings-Meuthen, PetraUNSPECIFIEDhttps://orcid.org/0000-0001-5291-4419UNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Mulder, EdwinUNSPECIFIEDhttps://orcid.org/0000-0003-1200-5792UNSPECIFIED
Jaspers, RichardVrije Universiteit AmsterdamUNSPECIFIEDUNSPECIFIED
Degens, HansManchester Metropolitan Universityhttps://orcid.org/0000-0001-7399-4841UNSPECIFIED
Wüst, RobVrije Universiteit Amsterdam, Amsterdam, The NetherlandsUNSPECIFIEDUNSPECIFIED
Date:16 January 2024
Journal or Publication Title:Cell Reports Medicine
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:5
DOI:10.1016/j.xcrm.2023.101372
Page Range:p. 101372
Publisher:Elsevier
Series Name:Cell Reports
ISSN:2666-3791
Status:Published
Keywords:bed rest, insulin sensitivity, skeletal muscle metabolism
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Kaiser-Stolz, Claudia
Deposited On:20 Mar 2024 09:13
Last Modified:20 Mar 2024 09:58

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