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Changes in real-world walking speed following 60-day bed-rest

Grassi, Marcello and von der Straten, Fiona and Pearce, Charlotte and Lee, Jessica K. and Mider, Marcin and Mittag, Uwe and Sies, Wolfram and Mulder, Edwin and Daumer, Martin and Rittweger, Jörn (2024) Changes in real-world walking speed following 60-day bed-rest. npj Microgravity, 10 (1), p. 6. Nature Publishing Group. doi: 10.1038/s41526-023-00342-8. ISSN 2373-8065.

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Official URL: https://www.nature.com/articles/s41526-023-00342-8

Abstract

The aim of this work was to explore whether real-world walking speed (RWS) would change as a consequence of 60-day bed-rest. The main hypothesis was that daily RWS would decrease after the bed-rest, with a subsequent recovery during the first days of re-ambulation. Moreover, an exploratory analysis was done in order to understand whether there is an agreement between the loss in RWS after bed-rest and the loss in the maximum oxygen uptake capacity (VO₂ₘₐₓ), or the loss in maximal vertical jump power (JUMP) respectively. Twenty-four subjects were randomly assigned to one of three groups: a continuous artificial gravity group, an intermittent artificial gravity group, or a control group. The fitted linear mixed effects model showed a significant decrease (p < 0.001) of RWS after the 60-day bed-rest and a subsequent increase (p < 0.001) of RWS during the 14-day recovery period in the study facility. No or little agreement was found between the loss in RWS and the loss in VO₂ₘₐₓ capacity or the loss in maximal vertical jumping power (RWS vs. VO₂ₘₐₓ: p = 0.81, RWS vs. JUMP: p = 0.173). Decreased RWS after bed-rest, with a follow-up recovery was observed for all three groups, regardless of the training intervention. This suggests that RWS, also in these settings, was able to reflect a de-conditioning and follow-up recovery process

Item URL in elib:https://elib.dlr.de/202641/
Document Type:Article
Title:Changes in real-world walking speed following 60-day bed-rest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Grassi, MarcelloSylvia Lawry Center for Multiple Sclerosis Research e.V., Munich, Germany; Institute of Aerospace Medicine, Department of Muscle and Bone Metabolism, German Aerospace Center, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
von der Straten, FionaTUM School for Computation, Information and Technology, Technical University of Munich, Munich, GermanyUNSPECIFIEDUNSPECIFIED
Pearce, CharlotteTUM School for Computation, Information and Technology, Technical University of Munich, Munich, GermanyUNSPECIFIEDUNSPECIFIED
Lee, Jessica K.German Aerospace Center, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Mider, MarcinTrium Analysis Online GmbH, Munich, GermanyUNSPECIFIEDUNSPECIFIED
Mittag, UweUNSPECIFIEDhttps://orcid.org/0000-0002-8580-3085UNSPECIFIED
Sies, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulder, EdwinInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Daumer, MartinSylvia Lawry Center for Multiple Sclerosis, The Human Motion Institute, Munich, Germany;TUM School for Computation, Information and Technology, Technical University of Munich, Munich, Germany; Trium Analysis Online GmbH, Munich, GermanyUNSPECIFIEDUNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Date:13 January 2024
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI:10.1038/s41526-023-00342-8
Page Range:p. 6
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:real-world walking speed (RWS), 60-day bed-rest, recovery process
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: Kaiser-Stolz, Claudia
Deposited On:07 Feb 2024 09:24
Last Modified:07 Feb 2024 12:31

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