elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Eye-brain axis microgravity and its implications for Spaceflight associated neuro-ocular Syndrome

Stern, C. and Yücel, Y. and zu Eulenberg, P. and Pavy-Le Traon, A. and Grove Petersen, L. (2023) Eye-brain axis microgravity and its implications for Spaceflight associated neuro-ocular Syndrome. npj Microgravity, 9 (1), p. 56. Nature Publishing Group. doi: 10.1038/s41526-023-00300-4. ISSN 2373-8065.

[img] PDF - Published version
890kB

Official URL: https://doi.org/10.1038/s41526-023-00300-4.

Abstract

Long-duration human spaceflight can lead to changes in both the eye and the brain, which have been referred to as Spaceflight Associated Neuro-ocular Syndrome (SANS). These changes may manifest as a constellation of symptoms, which can include optic disc edema, optic nerve sheath distension, choroidal folds, globe flattening, hyperopic shift, and cotton wool spots. Although the underpinning mechanisms for SANS are not yet known, contributors may include intracranial interstitial fluid accumulation following microgravity induced headward fluid shift. Development and validation of SANS countermeasures contribute to our understanding of etiology and accelerate new technology including exercise modalities, Lower Body Negative Pressure suits, venous thigh cuffs, and Impedance Threshold Devices. However, significant knowledge gaps remain including biomarkers, a full set of countermeasures and/or treatment regimes, and finally reliable ground based analogs to accelerate the research. This review from the European Space Agency SANS expert group summarizes past research and current knowledge on SANS, potential countermeasures, and key knowledge gaps, to further our understanding, prevention, and treatment of SANS both during human spaceflight and future extraterrestrial surface exploration.

Item URL in elib:https://elib.dlr.de/200964/
Document Type:Article
Title:Eye-brain axis microgravity and its implications for Spaceflight associated neuro-ocular Syndrome
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Stern, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yücel, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
zu Eulenberg, P.Institute for Neuroradiology, Ludwig-Maximilians-University Munich, Munich, Germanyhttps://orcid.org/0000-0002-3729-4570UNSPECIFIED
Pavy-Le Traon, A.Department of Neurology, French Reference Centre for Multiple System Atrophy, University Hospital of Toulouse, Toulouse, FranceUNSPECIFIEDUNSPECIFIED
Grove Petersen, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date:20 July 2023
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI:10.1038/s41526-023-00300-4
Page Range:p. 56
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:Schwerelosigkeit, Augen, neuro-okular Syndrome
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Operational Medicine
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Clinical Aerospace Medicine
Deposited By: Pittius, Maren
Deposited On:13 Dec 2023 10:31
Last Modified:18 Dec 2023 11:56

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Website and database design: Copyright © German Aerospace Center (DLR). All rights reserved.