Stern, C. und Yücel, Y. und zu Eulenberg, P. und Pavy-Le Traon, A. und Grove Petersen, L. (2023) Eye-brain axis microgravity and its implications for Spaceflight associated neuro-ocular Syndrome. npj Microgravity, 9 (1), Seite 56. Nature Publishing Group. doi: 10.1038/s41526-023-00300-4. ISSN 2373-8065.
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Offizielle URL: https://doi.org/10.1038/s41526-023-00300-4.
Kurzfassung
Long-duration human spaceflight can lead to changes in both the eye and the brain, which have been referred to as Spaceflight Associated Neuro-ocular Syndrome (SANS). These changes may manifest as a constellation of symptoms, which can include optic disc edema, optic nerve sheath distension, choroidal folds, globe flattening, hyperopic shift, and cotton wool spots. Although the underpinning mechanisms for SANS are not yet known, contributors may include intracranial interstitial fluid accumulation following microgravity induced headward fluid shift. Development and validation of SANS countermeasures contribute to our understanding of etiology and accelerate new technology including exercise modalities, Lower Body Negative Pressure suits, venous thigh cuffs, and Impedance Threshold Devices. However, significant knowledge gaps remain including biomarkers, a full set of countermeasures and/or treatment regimes, and finally reliable ground based analogs to accelerate the research. This review from the European Space Agency SANS expert group summarizes past research and current knowledge on SANS, potential countermeasures, and key knowledge gaps, to further our understanding, prevention, and treatment of SANS both during human spaceflight and future extraterrestrial surface exploration.
elib-URL des Eintrags: | https://elib.dlr.de/200964/ | ||||||||||||||||||||||||
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Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||
Titel: | Eye-brain axis microgravity and its implications for Spaceflight associated neuro-ocular Syndrome | ||||||||||||||||||||||||
Autoren: |
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Datum: | 20 Juli 2023 | ||||||||||||||||||||||||
Erschienen in: | npj Microgravity | ||||||||||||||||||||||||
Referierte Publikation: | Ja | ||||||||||||||||||||||||
Open Access: | Ja | ||||||||||||||||||||||||
Gold Open Access: | Ja | ||||||||||||||||||||||||
In SCOPUS: | Ja | ||||||||||||||||||||||||
In ISI Web of Science: | Ja | ||||||||||||||||||||||||
Band: | 9 | ||||||||||||||||||||||||
DOI: | 10.1038/s41526-023-00300-4 | ||||||||||||||||||||||||
Seitenbereich: | Seite 56 | ||||||||||||||||||||||||
Verlag: | Nature Publishing Group | ||||||||||||||||||||||||
ISSN: | 2373-8065 | ||||||||||||||||||||||||
Status: | veröffentlicht | ||||||||||||||||||||||||
Stichwörter: | Schwerelosigkeit, Augen, neuro-okular Syndrome | ||||||||||||||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||
HGF - Programm: | Raumfahrt | ||||||||||||||||||||||||
HGF - Programmthema: | Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||||||||||||||||||
DLR - Forschungsgebiet: | R FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - Operationelle Medizin | ||||||||||||||||||||||||
Standort: | Köln-Porz | ||||||||||||||||||||||||
Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Klinische Luft- und Raumfahrtmedizin | ||||||||||||||||||||||||
Hinterlegt von: | Pittius, Maren | ||||||||||||||||||||||||
Hinterlegt am: | 13 Dez 2023 10:31 | ||||||||||||||||||||||||
Letzte Änderung: | 18 Dez 2023 11:56 |
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