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Impact of microgravity on the gut microbiome and microenvironment during the AGBRESA bed rest study

Ramos-Nascimento, A. and Grenga, L. and Haange, S.-B. and Mulder, E. and Frings-Meuthen, P. and Hellweg, C.E. and Jordan, J. and RolleKampczyk, U. and Armengaud, J. and Moeller, R. (2023) Impact of microgravity on the gut microbiome and microenvironment during the AGBRESA bed rest study. 61. Jahrestagung der DGLRM, 2023-10-19 - 2023-10-21, Köln, Deutschland.

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Abstract

The Artificial Gravity Bed Rest – European Space Agency (AGBRESA) study was the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated weightlessness on the human body and assessed the potential benefits of artificial gravity as a countermeasure in an analog of long-duration spaceflight. In this study, we investigated the impact of simulated microgravity on the gut microbiome of 12 participants during a 60-day head-down tilt bed rest at the :envihab facilities. Over 60 days of simulated microgravity resulted in a mild change on the gut microbiome, with distinct microbial patterns and pathway expression in the feces of the countermeasure group compared to the microgravity simulation-only group. Additionally, we found that the countermeasure protocols selectively increased the abundance of beneficial short-chain fatty acids in the gut, such as acetate, butyrate, and propionate. Some physiological signatures also included the modulation of taxa reported to be either beneficial or opportunistic, indicating a mild adaptation in the microbiome network balance. Our results suggest that monitoring the gut microbial catalog along with pathway clustering and metabolite profiling is an informative synergistic strategy to determine health disturbances and the outcome of countermeasure protocols for future space missions.

Item URL in elib:https://elib.dlr.de/200628/
Document Type:Conference or Workshop Item (Speech)
Title:Impact of microgravity on the gut microbiome and microenvironment during the AGBRESA bed rest study
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Ramos-Nascimento, A.UNSPECIFIEDhttps://orcid.org/0000-0003-2437-3445UNSPECIFIED
Grenga, L.Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols sur Cèze, Francehttps://orcid.org/0000-0001-5560-1717UNSPECIFIED
Haange, S.-B.Department of Metabolomics, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germanyhttps://orcid.org/0000-0003-2952-1152UNSPECIFIED
Mulder, E.UNSPECIFIEDhttps://orcid.org/0000-0003-1200-5792UNSPECIFIED
Frings-Meuthen, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellweg, C.E.UNSPECIFIEDhttps://orcid.org/0000-0002-2223-3580UNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
RolleKampczyk, U.UFZ-Helmholtz Centre for Environmental Research LeipzigUNSPECIFIEDUNSPECIFIED
Armengaud, J.Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols sur Cèze, Francehttps://orcid.org/0000-0003-1589-445XUNSPECIFIED
Moeller, R.UNSPECIFIEDhttps://orcid.org/0000-0002-2371-0676UNSPECIFIED
Date:October 2023
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:microgravity, microenvironment, gut microbiome, AGBRESA bed rest study
Event Title:61. Jahrestagung der DGLRM
Event Location:Köln, Deutschland
Event Type:national Conference
Event Start Date:19 October 2023
Event End Date:21 October 2023
Organizer:Deutsche Gesellschaft für Luft- und Raumfahrtmedizin e.V.
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project ISS LIFE 2.0
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Kopp, Kerstin
Deposited On:08 Dec 2023 09:02
Last Modified:24 Apr 2024 21:01

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