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Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog

Tidwell, J.B. and Taylor, J.A. and Collins, H.R. and Chamberlin, J.H. and Barisano, G. and Sepehrband, F. and Turner, M.D. and Gauthier, G. and Mulder, E. and Gerlach, D.A. and Roberts, D.R. (2023) Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog. American Journal of Neuroradiology, 44 (9), pp. 1026-1031. American Society of Neuroradiology. doi: 10.3174/ajnr.A7949. ISSN 0195-6108.

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Official URL: https://dx.doi.org/10.3174/ajnr.A7949

Abstract

Background and purpose: A global decrease in brain perfusion has recently been reported during exposure to a ground-based spaceflight analog. Considering that CSF and glymphatic flow are hypothesized to be propelled by arterial pulsations, it is unknown whether a change in perfusion would impact these CSF compartments. The aim of the current study was to evaluate the relationship among changes in cerebral perfusion, ventricular volume, and perivascular space volume before, during, and after a spaceflight analog. Materials and methods: Eleven healthy participants underwent 30 days of bed rest at 6° head-down tilt with 0.5% atmospheric CO2 as a spaceflight analog. For each participant, 6 MR imaging brain scans, including perfusion and anatomic-weighted T1 sequences, were obtained before, during, and after the analog period. Global perfusion, ventricular volume, and perivascular space volume time courses were constructed and evaluated with repeated measures ANOVAs. Results: Global perfusion followed a divergent time trajectory from ventricular and perivascular space volume, with perfusion decreasing during the analog, whereas ventricular and perivascular space volume increased (P < .001). These patterns subsequently reversed during the 2-week recovery period. Conclusions: The patterns of change in brain physiology observed in healthy participants suggest a relationship between cerebral perfusion and CSF homeostasis. Further study is warranted to determine whether a causal relationship exists and whether similar neurophysiologic responses occur during spaceflight.

Item URL in elib:https://elib.dlr.de/199940/
Document Type:Article
Title:Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Tidwell, J.B.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0002-9349-5393UNSPECIFIED
Taylor, J.A.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0002-7834-6779UNSPECIFIED
Collins, H.R.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0002-2481-766XUNSPECIFIED
Chamberlin, J.H.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0002-7083-3492UNSPECIFIED
Barisano, G.Laboratory of Neuroimaging (F.S.), University of Southern California, Los Angeles, Californiahttps://orcid.org/0000-0001-5598-1369UNSPECIFIED
Sepehrband, F.Department of Neurosurgery (G.B.), Stanford University, Stanford, CaliforniaUNSPECIFIEDUNSPECIFIED
Turner, M.D.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0001-9298-3128UNSPECIFIED
Gauthier, G.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0002-3985-2871UNSPECIFIED
Mulder, E.UNSPECIFIEDhttps://orcid.org/0000-0003-1200-5792UNSPECIFIED
Gerlach, D.A.German Aerospace Center (DLR)https://orcid.org/0000-0001-7044-6065UNSPECIFIED
Roberts, D.R.From the Department of Radiology and Radiological Science (J.B.T., J.A.T., H.R.C., J.H.C., M.D.T., G.G., D.R.R.), Medical University of South Carolina; Charleston, South Carolinahttps://orcid.org/0000-0002-6302-8233UNSPECIFIED
Date:September 2023
Journal or Publication Title:American Journal of Neuroradiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:44
DOI:10.3174/ajnr.A7949
Page Range:pp. 1026-1031
Publisher:American Society of Neuroradiology
ISSN:0195-6108
Status:Published
Keywords:cerebral perfusion; perivascular space volume; ventricular volume; spaceflight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:05 Dec 2023 16:26
Last Modified:05 Dec 2023 16:26

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