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The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps

Olde Engberink, R.H.G. and van Oosten, P.J. and Weber, T. and Tabury, K. and Baatout, S. and Siew, K. and Walsh, S.B. and Valenti, G. and Choukèr, A. and Boutouyrie, P. and Heer, M. and Jordan, J. and Goswami, N. (2023) The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps. npj Microgravity, 9 (1), p. 29. Nature Publishing Group. doi: 10.1038/s41526-023-00268-1. ISSN 2373-8065.

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Official URL: https://dx.doi.org/10.1038/s41526-023-00268-1

Abstract

Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the renin-angiotensin-aldosterone system, the sympathetic nervous system, osmoregulatory responses, glomerular function, tubular function, and environmental factors such as sodium and water intake, motion sickness and ambient temperature make it difficult to establish the exact effect of microgravity and the subsequent fluid shifts and muscle mass loss on these parameters. Unfortunately, not all responses to actual microgravity can be reproduced with head-down tilt bed rest studies, which complicates research on Earth. Better understanding of the effects of microgravity on kidney function, volume regulation and osmoregulation are needed with the advent of long-term deep space missions and planetary surface explorations during which orthostatic intolerance complaints or kidney stone formation can be life-threatening for astronauts. Galactic cosmic radiation may be a new threat to kidney function. In this review, we summarise and highlight the current understandings of the effects of microgravity on kidney function, volume regulation and osmoregulation and discuss knowledge gaps that future studies should address.

Item URL in elib:https://elib.dlr.de/199915/
Document Type:Article
Title:The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Olde Engberink, R.H.G.Amsterdam UMC location University of Amsterdam, Department of Internal Medicine, Section of Nephrology, Meibergdreef 9, Amsterdam, The Netherlandshttps://orcid.org/0000-0002-3177-2279UNSPECIFIED
van Oosten, P.J.Amsterdam UMC location University of Amsterdam, Department of Internal Medicine, Section of Nephrology, Meibergdreef 9, Amsterdam, The NetherlandsUNSPECIFIEDUNSPECIFIED
Weber, T.Space Medicine Team, European Astronaut Centre (EAC), Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Tabury, K.Radiobiology Unit, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgiumhttps://orcid.org/0000-0002-8004-3718UNSPECIFIED
Baatout, S.Radiobiology Unit, Belgian Nuclear Research Centre, SCK CEN, Mol, BelgiumUNSPECIFIEDUNSPECIFIED
Siew, K.London Tubular Centre, UCL Department of Renal Medicine, University College London, London, UKUNSPECIFIEDUNSPECIFIED
Walsh, S.B.London Tubular Centre, UCL Department of Renal Medicine, University College London, London, UKUNSPECIFIEDUNSPECIFIED
Valenti, G.Department of Biosciences, Biotechnologies and Biopharmaceutics University of Bari, Bari, Italy.UNSPECIFIEDUNSPECIFIED
Choukèr, A.Department of Anaesthesiology, Hospital of the University of Munich, Marchioninistrasse 15, München, 81377, Germany.UNSPECIFIEDUNSPECIFIED
Boutouyrie, P.Université Paris Cité, Inserm, PARCC, F-75015, Paris, FranceUNSPECIFIEDUNSPECIFIED
Heer, M.German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Goswami, N.Gravitational Physiology and Medicine Research Unit, Division of Physiology, Otto Löwi Research Center of Vascular Biology, Inflammation, and Immunity, Medical University of Graz, Graz, Austriahttps://orcid.org/0000-0002-6704-0723UNSPECIFIED
Date:April 2023
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI:10.1038/s41526-023-00268-1
Page Range:p. 29
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:kidney; volume homeostasis; osmoregulation; space
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain, R - Bone metabolism and structural adaptation
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:05 Dec 2023 15:35
Last Modified:05 Dec 2023 15:35

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