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Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?

Harris, K.M. and Arya, R. and Elias, A. and Weber, T. and Green, D.A. and Greaves, D.K. and Petersen, L.G. and Robertson, L. and Kamine, T.H. and Mazzolai, L. and Bergauer, A. and Kim, D.S. and Olde Engberink, R.H. and zu Eulenberg, P. and Grassi, B. and Zuccarelli, L. and Baldassarre, G. and Tabury, K. and Baatout, S. and Jordan, J. and Blaber, A.P. and Choukèr, A. and Russomano, T. and Goswami, N. (2023) Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now? npj Microgravity, 9 (1), p. 17. Nature Publishing Group. doi: 10.1038/s41526-023-00260-9. ISSN 2373-8065.

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Official URL: https://dx.doi.org/10.1038/s41526-023-00260-9


The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.

Item URL in elib:https://elib.dlr.de/199909/
Document Type:Article
Title:Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Harris, K.M.Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canadahttps://orcid.org/0000-0001-6705-9830UNSPECIFIED
Arya, R.Kings College Hospital, NHS Foundation Trust, London, UKUNSPECIFIEDUNSPECIFIED
Elias, A.Department of Vascular Medicine, Sainte Musse Hospital, Toulon La Seyne Hospital Centre, Toulon, FranceUNSPECIFIEDUNSPECIFIED
Weber, T.European Astronaut Centre (EAC), European Space Agency, Space Medicine Team (HRE-OM), Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Green, D.A.European Astronaut Centre (EAC), European Space Agency, Space Medicine Team (HRE-OM), Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Greaves, D.K.Faculty of Health, University of Waterloo, Waterloo, Canadahttps://orcid.org/0000-0001-5188-086XUNSPECIFIED
Petersen, L.G.Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkUNSPECIFIEDUNSPECIFIED
Robertson, L.Kings College Hospital, NHS Foundation Trust, London, UKUNSPECIFIEDUNSPECIFIED
Kamine, T.H.Division of Trauma, Acute Care Surgery, and Surgical Critical Care, Baystate Medical Center, Springfield, MA, United StatesUNSPECIFIEDUNSPECIFIED
Mazzolai, L.Department of Angiology, Centre Hospitalier Universitaire Vaudois, Lausanne, SwitzerlandUNSPECIFIEDUNSPECIFIED
Bergauer, A.Surgery, LKH Südsteiermark, Wagna, AustriaUNSPECIFIEDUNSPECIFIED
Kim, D.S.Space Medicine Team, European Astronaut Centre, European Space Agency, Cologne, Germanyhttps://orcid.org/0000-0002-8097-810XUNSPECIFIED
Olde Engberink, R.H.Amsterdam UMC location University of Amsterdam, Department of Internal Medicine, Section of Nephrology, Amsterdam, The Netherlandshttps://orcid.org/0000-0002-3177-2279UNSPECIFIED
zu Eulenberg, P.Institute for Neuroradiology, Ludwig-Maximilians-University Munich, Munich, Germanyhttps://orcid.org/0000-0002-3729-4570UNSPECIFIED
Grassi, B.University of Udine, ItalyUNSPECIFIEDUNSPECIFIED
Zuccarelli, L.Department of Medicine, University of Udine, Udine, Italyhttps://orcid.org/0000-0003-2447-4684UNSPECIFIED
Baldassarre, G.Department of Medicine, University of Udine, Udine, ItalyUNSPECIFIEDUNSPECIFIED
Tabury, K.Radiobiology Unit, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgiumhttps://orcid.org/0000-0002-8004-3718UNSPECIFIED
Baatout, S.Radiobiology Unit, Belgian Nuclear Research Centre, SCK CEN, Mol, BelgiumUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Blaber, A.P.Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaUNSPECIFIEDUNSPECIFIED
Choukèr, A.Department of Anaesthesiology, Hospital of the University of Munich, Marchioninistrasse 15, München, 81377, Germany.UNSPECIFIEDUNSPECIFIED
Russomano, T.Translational Research Stress & Immunity, Klinik für Anästhesiologie/Forschungslabors, LMU Klinikum, München, GermanyUNSPECIFIEDUNSPECIFIED
Goswami, N.Division of Physiology, Otto Löwi Research Center for Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, AustriaUNSPECIFIEDUNSPECIFIED
Date:February 2023
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:p. 17
Publisher:Nature Publishing Group
Keywords:Pathophysiology; venous thrombosis; space
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain, R - Bone metabolism and structural adaptation
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:05 Dec 2023 15:29
Last Modified:05 Dec 2023 15:29

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