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Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest

Hönemann, J. and Möstl, S. and van Herwaarden, A.E. and Diedrich, A. and Mulder, E. and Frett, T. and Petrat, G. and Pustowalow, W. and Arz, M. and Heusser, K. and Lee, S. and Jordan, J. and Tank, J. and Hoffmann, F. (2023) Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest. Clinical Autonomic Research, 33 (4), pp. 401-410. Springer. doi: 10.1007/s10286-023-00959-5. ISSN 0959-9851.

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Official URL: https://doi.org/10.1007/s10286-023-00959-5

Abstract

Purpose: Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tolerance following head-down tilt bedrest, which is an established terrestrial model for weightlessness. Methods: We studied 24 healthy persons (eight women; age 33.3 ± 9.0 years; BMI 24.3 ± 2.1 kg/m²) who participated in the 60-days head-down tilt bedrest (AGBRESA) study. They were assigned to 30 min/day continuous or 6 × 5 min intermittent short-arm centrifugation with 1Gz at the center of mass or a control group. We performed head-up tilt testing with incremental lower-body negative pressure until presyncope before and after bedrest. We recorded an electrocardiogram, beat-to-beat finger blood pressure, and brachial blood pressure and obtained blood samples from an antecubital venous catheter. Orthostatic tolerance was defined as time to presyncope. We related changes in orthostatic tolerance to changes in plasma volume determined by carbon dioxide rebreathing. Results: Compared with baseline measurements, supine and upright heart rate increased in all three groups following head-down tilt bedrest. Compared with baseline measurements, time to presyncope decreased by 323 ± 235 s with continuous centrifugation, by 296 ± 508 s with intermittent centrifugation, and by 801 ± 354 s in the control group (p = 0.0249 between interventions). The change in orthostatic tolerance was not correlated with changes in plasma volume. Conclusions: Daily artificial gravity training on a short-arm centrifuge attenuated the reduction in orthostatic tolerance after 60 days of head-down tilt bedrest.

Item URL in elib:https://elib.dlr.de/199802/
Document Type:Article
Title:Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Hönemann, J.German Aerospace Center - DLR, Institute of Aerospace Medicine, Linder Hoehe, 51147, Cologne, Germany and Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Möstl, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Herwaarden, A.E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIEDUNSPECIFIED
Mulder, E.UNSPECIFIEDhttps://orcid.org/0000-0003-1200-5792UNSPECIFIED
Frett, T.UNSPECIFIEDhttps://orcid.org/0000-0002-5572-1177UNSPECIFIED
Petrat, G.UNSPECIFIEDhttps://orcid.org/0000-0001-5725-8908UNSPECIFIED
Pustowalow, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arz, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heusser, K.UNSPECIFIEDhttps://orcid.org/0000-0002-2571-5585UNSPECIFIED
Lee, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Hoffmann, F.German Aerospace Center - DLR, Institute of Aerospace Medicine, Linder Hoehe, 51147, Cologne, Germany and Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Date:22 June 2023
Journal or Publication Title:Clinical Autonomic Research
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:33
DOI:10.1007/s10286-023-00959-5
Page Range:pp. 401-410
Publisher:Springer
ISSN:0959-9851
Status:Published
Keywords:Artificial gravity; Bedrest; Cardiovascular deconditioning; Orthostatic tolerance
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:05 Dec 2023 14:20
Last Modified:05 Dec 2023 14:20

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