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Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus

Heußer, K. and Tank, J. and Diedrich, A. and Fischer, A. and Heise, T. and Jordan, J. (2023) Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus. Frontiers in Neuroscience, 16, p. 1107752. Frontiers Media S.A.. doi: 10.3389/fnins.2022.1107752. ISSN 1662-4548.

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Official URL: https://doi.org/10.3389/fnins.2022.1107752

Abstract

Introduction: Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, data on sympathetic activity in this population is scarce. Methods: We studied 61 patients with type 2 diabetes mellitus (22 women, 60.9 ± 1.4 years; 39 men, 60.9 ± 1.4 years). They had to have diabetes for at least 2 years, a hemoglobin A1c of 6.5-10%, a body-mass-index of 20-40 kg/m2, and had to be treated with stable doses of metformin only. We recorded ECG, finger and brachial blood pressure, and muscle sympathetic nerve activity (MSNA). Results: MSNA was 37.5 ± 2.5 bursts/min in women and 39.0 ± 2.0 bursts/min in men (p = 0.55). MSNA expressed as burst incidence was 52.7 ± 2.0 bursts/100 beats in women and 59.2 ± 3.1 bursts/100 beats in men (p = 0.21). Five out of 39 men (12.8%) and two out of 22 women (9.1%) exhibited resting MSNA measurements above the 95th percentile for sex and age. In the pooled analysis, MSNA was not significantly correlated with systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, body composition, or HbA1c (r 2 < 0.02, p > 0.26 for all). Discussion: We conclude that relatively few older patients with type 2 diabetes mellitus exhibit increased MSNA. The large interindividual variability in MSNA cannot be explained by gender, blood pressure, body mass index, or glycemic control.

Item URL in elib:https://elib.dlr.de/199580/
Document Type:Article
Title:Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Heußer, K.UNSPECIFIEDhttps://orcid.org/0000-0002-2571-5585UNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIEDUNSPECIFIED
Fischer, A.Profil Institut für Stoffwechselforschung GmbH, Neuss, GermanyUNSPECIFIEDUNSPECIFIED
Heise, T.Profil Institut für Stoffwechselforschung GmbH, Neuss, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Date:12 January 2023
Journal or Publication Title:Frontiers in Neuroscience
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:16
DOI:10.3389/fnins.2022.1107752
Page Range:p. 1107752
Publisher:Frontiers Media S.A.
ISSN:1662-4548
Status:Published
Keywords:autonomic nervous system; blood pressure; microneurography; sympathetic activity; type 2 diabetes mellitus
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:23 Nov 2023 13:49
Last Modified:23 Nov 2023 13:49

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