External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial

Borschert, Borschert and Gauger, Peter and Bach, Anja and Gerlach, Darius and Johannes, Bernd and Jordan, Jens and Li, Zhili and Elmenhorst, David and Bauer, Andreas and Marshall-Goebel, Karina and Tank, Jens and Zange, Jochen and Rittweger, Jörn (2023) External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial. npj Microgravity, 9 (1), p. 25. Nature Publishing Group. doi: 10.1038/s41526-023-00267-2. ISSN 2373-8065.

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Official URL: https://doi.org/10.1038/s41526-023-00267-2

Abstract

The exact pathophysiology of the spaceflight-associated neuro-ocular syndrome (SANS) has so far not been completely elucidated. In this study we assessed the effect of acute head-down tilt position on the mean flow of the intra- and extracranial vessels. Our results suggest a shift from the external to the internal system that might play an important role in the pathomechanism of SANS.

Item URL in elib:

https://elib.dlr.de/199011/

Document Type:

Article

Title:

External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
Borschert, Borschert	DLR, Institut für Luft- und Raumfahrtmedizin	UNSPECIFIED	UNSPECIFIED
Gauger, Peter	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Bach, Anja	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Gerlach, Darius	UNSPECIFIED	https://orcid.org/0000-0001-7044-6065	UNSPECIFIED
Johannes, Bernd	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Jordan, Jens	Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany	https://orcid.org/0000-0003-4518-0706	UNSPECIFIED
Li, Zhili	China Astronaut Research and Training Center, Beijing, China.	UNSPECIFIED	UNSPECIFIED
Elmenhorst, David	Molekulares Neuroimaging, Forschungszentrum Jülich	UNSPECIFIED	UNSPECIFIED
Bauer, Andreas	Forschungszentrum Jülich	UNSPECIFIED	UNSPECIFIED
Marshall-Goebel, Karina	Neural Systems Group, Massachusetts General Hospital, Harvard Medical School,	https://orcid.org/0000-0002-5240-7625	UNSPECIFIED
Tank, Jens	UNSPECIFIED	https://orcid.org/0000-0002-5672-1187	UNSPECIFIED
Zange, Jochen	UNSPECIFIED	https://orcid.org/0000-0003-1822-0952	146682071
Rittweger, Jörn	UNSPECIFIED	https://orcid.org/0000-0002-2223-8963	UNSPECIFIED

Date:

28 March 2023

Journal or Publication Title:

npj Microgravity

Refereed publication:

Yes

Open Access:

Yes

Gold Open Access:

Yes

In SCOPUS:

Yes

In ISI Web of Science:

Yes

Volume:

DOI:

10.1038/s41526-023-00267-2

Page Range:

p. 25

Publisher:

Nature Publishing Group

ISSN:

2373-8065

Status:

Published

Keywords:

spaceflight-associated neuro-ocular syndrome, magnetic resonance imaging, brain perfusion, flow imaging

HGF - Research field:

Aeronautics, Space and Transport

HGF - Program:

Space

HGF - Program Themes:

Research under Space Conditions

DLR - Research area:

Raumfahrt

DLR - Program:

R FR - Research under Space Conditions

DLR - Research theme (Project):

R - Human performance under altered gravity conditions

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME

Deposited By:

Zange, Dr.rer.nat. Jochen

Deposited On:

15 Nov 2023 14:27

Last Modified:

22 Nov 2023 08:24

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