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External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial

Borschert, Borschert and Gauger, Peter and Bach, Anja and Gerlach, Darius and Johannes, Bernd and Jordan, Jens and Li, Zhili and Elmenhorst, David and Bauer, Andreas and Marshall-Goebel, Karina and Tank, Jens and Zange, Jochen and Rittweger, Jörn (2023) External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial. npj Microgravity, 9 (1), p. 25. Nature Publishing Group. doi: 10.1038/s41526-023-00267-2. ISSN 2373-8065.

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Official URL: https://doi.org/10.1038/s41526-023-00267-2

Abstract

The exact pathophysiology of the spaceflight-associated neuro-ocular syndrome (SANS) has so far not been completely elucidated. In this study we assessed the effect of acute head-down tilt position on the mean flow of the intra- and extracranial vessels. Our results suggest a shift from the external to the internal system that might play an important role in the pathomechanism of SANS.

Item URL in elib:https://elib.dlr.de/199011/
Document Type:Article
Title:External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Borschert, BorschertDLR, Institut für Luft- und RaumfahrtmedizinUNSPECIFIEDUNSPECIFIED
Gauger, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bach, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, DariusUNSPECIFIEDhttps://orcid.org/0000-0001-7044-6065UNSPECIFIED
Johannes, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Li, ZhiliChina Astronaut Research and Training Center, Beijing, China.UNSPECIFIEDUNSPECIFIED
Elmenhorst, DavidMolekulares Neuroimaging, Forschungszentrum JülichUNSPECIFIEDUNSPECIFIED
Bauer, AndreasForschungszentrum JülichUNSPECIFIEDUNSPECIFIED
Marshall-Goebel, KarinaNeural Systems Group, Massachusetts General Hospital, Harvard Medical School,https://orcid.org/0000-0002-5240-7625UNSPECIFIED
Tank, JensUNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Zange, JochenUNSPECIFIEDhttps://orcid.org/0000-0003-1822-0952146682071
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Date:28 March 2023
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:9
DOI:10.1038/s41526-023-00267-2
Page Range:p. 25
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:spaceflight-associated neuro-ocular syndrome, magnetic resonance imaging, brain perfusion, flow imaging
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Human performance under altered gravity conditions
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:15 Nov 2023 14:27
Last Modified:22 Nov 2023 08:24

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