Pesta, Dominik and Heieis, Jule and Hand, Olga and Frings-Meuthen, Petra and Marcus, Katrin and Clemen, Christoph S. and Levine, Ben and Sadek, Hesham and Hoffmann, Fabian and Limper, Ulrich and Jordan, Jens and Sies, Wolfram and Tank, Jens and Zange, Jochen and Rittweger, Jörn (2023) Case Report: Muscle wasting during severe sustained hypoxia in two professional mountaineers. Medicine and Science in Sports and Exercise, 55 (3), pp. 335-341. Lippincott Williams & Wilkins Ltd.. doi: 10.1249/MSS.0000000000003060. ISSN 0195-9131.
Full text not available from this repository.
Official URL: https://doi.org/10.1249/MSS.0000000000003060
Abstract
Purpose: Chronic exposure to hypoxia can induce muscle wasting in unaccustomed individuals. Detailed assessment of the effects of hypoxia on muscle tissue adaptation in elite mountaineers has not been performed. This study aims to assess muscle volume after exposure to normobaric hypoxia. Methods: Two professional mountaineers (A and B) participated in a 35-d intervention of graded normobaric hypoxia with the aim of 14 d exposure to 8% oxygen corresponding to 7112-m altitude. Volume of the shank, thigh, and hip muscles was assessed by magnetic resonance imaging pre- and postintervention. Dietary intake and physical activity were monitored throughout the study from food images and accelerometry analysis, together with blood analysis and anthropometric measurements. Results: Hypoxia reduced total leg muscle volume by 3.3% ± 6.0% in A and by 9.4% ± 7.3% in B. A lost 288 g and B 642 g of muscle mass, whereas dietary intake only declined by ~23% in the last intervention week. Arterial oxygen saturation declined from 95% and 86% to 77% and 72% in A and B, respectively. In hypoxia, participants could not maintain their physical activity levels. Notably, muscle loss varied substantially across muscle groups amounting to 5.4% ± 3.0%, 8.3% ± 5.2%, and 4.1% ± 8.6% for hip, thigh, and shank muscles, respectively. Conclusions: Our results indicate that hypoxia and resultant reductions in physical activity and caloric intake lead to substantial loss of muscle mass that was accentuated in proximal muscle as opposed to distal muscles. Surprisingly, thigh muscle wasting during this intervention is comparable with that observed during strict 56-d bed rest.
Item URL in elib: | https://elib.dlr.de/195122/ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Document Type: | Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Title: | Case Report: Muscle wasting during severe sustained hypoxia in two professional mountaineers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Authors: |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date: | March 2023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Medicine and Science in Sports and Exercise | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In SCOPUS: | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In ISI Web of Science: | No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 55 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1249/MSS.0000000000003060 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 335-341 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Lippincott Williams & Wilkins Ltd. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 0195-9131 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Status: | Published | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Keywords: | hypoxia, muscle mass, muscle wasting, altitude | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Program: | Space | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DLR - Research theme (Project): | R - NeuroSpace | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Gravitational Biology Institute of Aerospace Medicine > Leitungsbereich ME Institute of Aerospace Medicine > Muscle and Bone Metabolism Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Deposited By: | Chiodo, Annette | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Deposited On: | 31 May 2023 11:43 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Last Modified: | 31 May 2023 11:43 |
Repository Staff Only: item control page