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Case Report: Muscle wasting during severe sustained hypoxia in two professional mountaineers

Pesta, Dominik and Heieis, Jule and Hand, Olga and Frings-Meuthen, Petra and Marcus, Katrin and Clemen, Christoph S. and Levine, Ben and Sadek, Hesham and Hoffmann, Fabian and Limper, Ulrich and Jordan, Jens and Sies, Wolfram and Tank, Jens and Zange, Jochen and Rittweger, Jörn (2023) Case Report: Muscle wasting during severe sustained hypoxia in two professional mountaineers. Medicine and Science in Sports and Exercise, 55 (3), pp. 335-341. Wolters Kluwer Health. doi: 10.1249/MSS.0000000000003060. ISSN 0195-9131.

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Official URL: https://doi.org/10.1249/MSS.0000000000003060

Abstract

Purpose: Chronic exposure to hypoxia can induce muscle wasting in unaccustomed individuals. Detailed assessment of the effects of hypoxia on muscle tissue adaptation in elite mountaineers has not been performed. This study aims to assess muscle volume after exposure to normobaric hypoxia. Methods: Two professional mountaineers (A and B) participated in a 35-d intervention of graded normobaric hypoxia with the aim of 14 d exposure to 8% oxygen corresponding to 7112-m altitude. Volume of the shank, thigh, and hip muscles was assessed by magnetic resonance imaging pre- and postintervention. Dietary intake and physical activity were monitored throughout the study from food images and accelerometry analysis, together with blood analysis and anthropometric measurements. Results: Hypoxia reduced total leg muscle volume by 3.3% ± 6.0% in A and by 9.4% ± 7.3% in B. A lost 288 g and B 642 g of muscle mass, whereas dietary intake only declined by ~23% in the last intervention week. Arterial oxygen saturation declined from 95% and 86% to 77% and 72% in A and B, respectively. In hypoxia, participants could not maintain their physical activity levels. Notably, muscle loss varied substantially across muscle groups amounting to 5.4% ± 3.0%, 8.3% ± 5.2%, and 4.1% ± 8.6% for hip, thigh, and shank muscles, respectively. Conclusions: Our results indicate that hypoxia and resultant reductions in physical activity and caloric intake lead to substantial loss of muscle mass that was accentuated in proximal muscle as opposed to distal muscles. Surprisingly, thigh muscle wasting during this intervention is comparable with that observed during strict 56-d bed rest.

Item URL in elib:https://elib.dlr.de/195122/
Document Type:Article
Title:Case Report: Muscle wasting during severe sustained hypoxia in two professional mountaineers
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Pesta, DominikUNSPECIFIEDhttps://orcid.org/0000-0002-5089-3586UNSPECIFIED
Heieis, JuleGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Hand, OlgaGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Frings-Meuthen, PetraGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Marcus, KatrinRuhr-University Bochum (RUB), Medical Faculty, Medical Proteom-Centre, Bochum, GermanyUNSPECIFIEDUNSPECIFIED
Clemen, Christoph S.German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germanyhttps://orcid.org/0000-0002-1291-4219UNSPECIFIED
Levine, BenInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, DallasUNSPECIFIEDUNSPECIFIED
Sadek, HeshamDepartment of Internal Medicine, University of Texas Southwestern Medical Center, DallasUNSPECIFIEDUNSPECIFIED
Hoffmann, FabianGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Limper, UlrichGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germanyhttps://orcid.org/0000-0001-9927-4180UNSPECIFIED
Jordan, JensGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germanyhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Sies, WolframGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Tank, JensGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cardiovascular Aerospace Medicine, Cologne, Germanyhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Zange, JochenGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Muscle- and Bone Metabolism, Cologne, Germanyhttps://orcid.org/0000-0003-1822-0952136033523
Rittweger, JörnGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Muscle- and Bone Metabolism, Cologne, Germanyhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Date:March 2023
Journal or Publication Title:Medicine and Science in Sports and Exercise
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:55
DOI:10.1249/MSS.0000000000003060
Page Range:pp. 335-341
Publisher:Wolters Kluwer Health
ISSN:0195-9131
Status:Published
Keywords:hypoxia, muscle mass, muscle wasting, altitude
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - NeuroSpace
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Chiodo, Annette
Deposited On:31 May 2023 11:43
Last Modified:22 Jan 2025 11:41

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