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Capillary rarefaction during bed rest is proportionally less than fibre atrophy and loss of oxidative capacity

Hendrickse, Paul William and Wüst, Rob and Ganse, Bergita and Giakoumaki, Ifigeneia and Rittweger, Jörn and Bosutti, Alessandra and Degens, Hans (2022) Capillary rarefaction during bed rest is proportionally less than fibre atrophy and loss of oxidative capacity. Journal of Sarcopenia, Cachexia and Muscle, 13 (6), pp. 2712-2723. Wiley. doi: 10.1002/jcsm.13072. ISSN 2190-5991.

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Official URL: https://doi.org/10.1002/jcsm.13072


Background Muscle disuse from bed rest or spaceflight results in losses in muscle mass, strength and oxidative capacity. Capillary rarefaction may contribute to muscle atrophy and the reduction in oxidative capacity during bed rest. Artificial gravity may attenuate the negative effects of long-term space missions or bed rest. The aim of the present study was to assess (1) the effects of bed rest on muscle fibre size, fibre type composition, capillarization and oxidative capacity in the vastus lateralis and soleus muscles after 6 and 55 days of bed rest and (2) the effectiveness of artificial gravity in mitigating bed-rest-induced detriments to these parameters

Item URL in elib:https://elib.dlr.de/193878/
Document Type:Article
Title:Capillary rarefaction during bed rest is proportionally less than fibre atrophy and loss of oxidative capacity
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Hendrickse, Paul WilliamManchester Metropolitan UniversityUNSPECIFIEDUNSPECIFIED
Wüst, RobVrije Universiteit Amsterdam, Amsterdam, The NetherlandsUNSPECIFIEDUNSPECIFIED
Ganse, BergitaSaarland University, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Giakoumaki, IfigeneiaManchester Metropolitan University, Manchester, UKUNSPECIFIEDUNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Bosutti, AlessandraDepartment of Clinical, Technological and Morphological Sciences, Division of Internal Medicine, University Triest, ItalienUNSPECIFIEDUNSPECIFIED
Degens, HansManchester Metropolitan Universityhttps://orcid.org/0000-0001-7399-4841UNSPECIFIED
Date:13 September 2022
Journal or Publication Title:Journal of Sarcopenia, Cachexia and Muscle
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 2712-2723
Keywords:Bed rest; Atrophy; Skeletal muscle; Artificial gravity; Capillarization; Oxidative capacity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Kaiser-Stolz, Claudia
Deposited On:14 Feb 2023 07:01
Last Modified:15 Feb 2023 08:42

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