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Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration

Liphardt, Anna Maria and Fernando-Gonzalo, Rodrigo and Albracht, Kirsten and Rittweger, Jörn and Vico, Laurence (2023) Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration. npj Microgravity, 9 (1), p. 9. Nature Publishing Group. doi: 10.1038/s41526-023-00258-3. ISSN 2373-8065.

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Official URL: https://doi.org/10.1038/s41526-023-00258-3


Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper "Human Physiology - Musculoskeletal system", this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.

Item URL in elib:https://elib.dlr.de/193768/
Document Type:Article
Title:Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Liphardt, Anna MariaUniversitätsklinik ErlangenUNSPECIFIEDUNSPECIFIED
Fernando-Gonzalo, RodrigoUnit of Clinical Physiology, Karolinska University Hospital, Hälsovägen 13, 14157, Huddinge, Sweden.UNSPECIFIEDUNSPECIFIED
Albracht, KirstenGerman Sport University Colognehttps://orcid.org/0000-0002-4271-2511UNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Vico, LaurenceUniv. Jean Monnet, Mines Saint-Étienne, INSERM, U 1059 Sainbiose, 42023, Saint-Étienne, France.UNSPECIFIEDUNSPECIFIED
Date:28 January 2023
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:p. 9
Publisher:Nature Publishing Group
Keywords:musculoskeletal system, long-term space flight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Muscle Mechanics and Metabolism
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Kaiser-Stolz, Claudia
Deposited On:02 Feb 2023 11:30
Last Modified:02 Feb 2023 11:30

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