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Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS)

Johansson, Madeleine and Fedorowski, Artur and Jordan, Jens and Engström, Gunnar and Nilsson, Peter M. and Hamrefors, Viktor (2022) Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS). Clinical Autonomic Research, 33 (1), pp. 29-40. Springer. doi: 10.1007/s10286-022-00911-z. ISSN 0959-9851.

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Official URL: https://dx.doi.org/10.1007/s10286-022-00911-z

Abstract

Purpose Arterial stiffness is independently associated with orthostatic hypotension in older individuals. The relationship between orthostatic blood pressure adaptation and aortic stiffness has not been thoroughly examined in a younger population. We investigated the relationship between orthostatic blood pressure adaptations, central aortic hemodynamics, and aortic stiffness in a cohort of predominantly younger and middle-aged adults. Methods We analyzed an observational, population-based study of 5259 individuals living in Malmö, Sweden. We related aortic stiffness and central hemodynamics assessed by carotid–femoral pulse wave velocity and pulse wave analysis at the arteria radialis using Sphygmocor to orthostatic blood pressure adaptation after 3 min standing. Results The mean age of the population was 41.9 ±14.5 years, and 52.1% were women. We observed the highest aortic stiffness and central aortic blood pressure measurements in the lowest and highest quartiles of orthostatic systolic blood pressure differences (p < 0.001). Aortic stiffness and central aortic blood pressure gradually decreased across increasing quartiles of orthostatic diastolic blood pressure difference (p<0.001). After full adjustment, orthostatic diastolic blood pressure remained significantly associated with aortic stiffness (p = 0.001) and central aortic blood pressure (p < 0.001), whereas orthostatic systolic blood pressure was significantly associated only with central aortic systolic blood pressure (p=0.009). No significant associations were found between subclinical orthostatic hypotension, aortic stiffness, and central hemodynamics. Conclusions Our findings demonstrate that altered blood pressure responses to orthostatic challenges, both blood pressure reductions and blood pressure increases, are independently and inversely associated with markers of aortic stiffness (vascular aging) in a predominantly young to middle-aged population.

Item URL in elib:https://elib.dlr.de/192984/
Document Type:Article
Title:Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS)
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Johansson, MadeleineUNSPECIFIEDhttps://orcid.org/0000-0001-9057-9148UNSPECIFIED
Fedorowski, ArturClinical Research Center, Department of Clinical Sciences-Hypertension and Cardiovascular Disease, Lund University, P.O. Box 50332, 202 13 Malmö, Sweden and Department of Cardiology, Karolinska University Hospital, Stockholm, Swedenhttps://orcid.org/0000-0002-5352-6327UNSPECIFIED
Jordan, JensUNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Engström, GunnarClinical Research Center, Department of Clinical Sciences-Hypertension and Cardiovascular Disease, Lund University, P.O. Box 50332, 202 13 Malmö, Swedenhttps://orcid.org/0000-0002-8618-9152UNSPECIFIED
Nilsson, Peter M.Clinical Research Center, Department of Clinical Sciences-Hypertension and Cardiovascular Disease, Lund University, P.O. Box 50332, 202 13 Malmö, Swedenhttps://orcid.org/0000-0002-5652-8459UNSPECIFIED
Hamrefors, ViktorClinical Research Center, Department of Clinical Sciences-Hypertension and Cardiovascular Disease, Lund University, P.O. Box 50332, 202 13 Malmö, Sweden and Department of Cardiology, Skåne University Hospital, Malmö, Swedenhttps://orcid.org/0000-0002-8475-0866UNSPECIFIED
Date:6 December 2022
Journal or Publication Title:Clinical Autonomic Research
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:33
DOI:10.1007/s10286-022-00911-z
Page Range:pp. 29-40
Publisher:Springer
ISSN:0959-9851
Status:Published
Keywords:Aortic stiffness, Arterial stiffness, Blood pressure, Epidemiology, Orthostatic hypotension, Population study, Vascular aging
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Kopp, Kerstin
Deposited On:09 Jan 2023 14:39
Last Modified:28 Jun 2023 11:22

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