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Hypothalamic nuclei activity and connectivity changes following a glucose challenge: a single subject fMRI study

Manuel, J. and Gerlach, D.A. and Halbe, E. and Heusser, K. and Ewald, A.C. and Hoff, A. and De Gioannis, R. and Heer, M. and Tank, J. and Jordan, J. (2022) Hypothalamic nuclei activity and connectivity changes following a glucose challenge: a single subject fMRI study. 33rd International Symposium on the Autonomic Nervous System, 02.-05. Nov. 2022, Hawaii.

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Introduction: Hypothalamic neural circuits, which adjust efferent autonomic activity in the face of altered nutrient supply, have been implicated in the pathogenesis of obesity, obesity-associated hypertension, and type 2 diabetes mellitus. Recent advances in functional magnetic resonance imaging (fMRI) permit to capture hypothalamic activity changes in groups of subjects. Because the approach obscures interindividual variability in hypothalamic regulation, we studied individual hypothalamic activity and functional connectivity in a single subject during multiple glucose challenges in the MRI scanner. Methods: We conducted ten oral glucose tolerance tests at different days in the same healthy man (56 years, 64 kg, 1.77 m). We acquired functional images using a 3 T scanner before, and 10 and 45 min after glucose ingestion. Moreover, we measured plasma glucose and insulin levels at seven time points in three of the tests. Activity and functional connectivity changes were calculated using independent component analysis followed by a dual regression using an F-test and post-hoc two-sample t-tests. All analyses were corrected for multiple comparisons. Results: Plasma glucose (147.5 ± 8.4 mg/dl) peaked 30 min after glucose intake followed by an insulin maximum 15 min thereafter (45.7 ± 7.0 mU/l). We observed significant activity increases 45 min after glucose intake in the arcuate, paraventricular, and dorsomedial nuclei, as well as in the posterior hypothalamic area, infundibulum, and mamillary bodies. Moreover, the mamillary bodies increased their functional connectivity to the ventromedial, dorsomedial, and periventricular nuclei. Conclusion: Our results, which are consistent with previous animal experiments, show that fMRI can capture individual activity and connectivity changes in specific hypothalamic nuclei during a glucose challenge. Individual hypothalamic fMRI holds promise in delineating disease mechanisms in single patients

Item URL in elib:https://elib.dlr.de/190425/
Document Type:Conference or Workshop Item (Poster)
Title:Hypothalamic nuclei activity and connectivity changes following a glucose challenge: a single subject fMRI study
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Manuel, J.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany and Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIEDUNSPECIFIED
Gerlach, D.A.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0001-7044-6065UNSPECIFIED
Halbe, E.Institute of Psychiatry and Psychotherapy, Universitätsklinikum Bonn, Bonn, GermanyUNSPECIFIEDUNSPECIFIED
Heusser, K.UNSPECIFIEDhttps://orcid.org/0000-0002-2571-5585UNSPECIFIED
Ewald, A.C.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Hoff, A.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
De Gioannis, R.Department of Internal Medicine, University of Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Heer, M.IU International University of Applied Sciences, Erfurt, GermanyUNSPECIFIEDUNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:No
Keywords:fMRI; hypothalamic nuclei activity; glucose; single subject study
Event Title:33rd International Symposium on the Autonomic Nervous System
Event Location:Hawaii
Event Type:international Conference
Event Dates:02.-05. Nov. 2022
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:22 Nov 2022 13:08
Last Modified:22 Nov 2022 13:08

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