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Autonomic cardiovascular control following 30 days strict head down tilt bedrest with six hours of daily lower body negative pressure training

Möstl, S. und Hönemann, J. und Diedrich, A. und Souza, H.C.D. und Jordan, J. und Tank, J. (2022) Autonomic cardiovascular control following 30 days strict head down tilt bedrest with six hours of daily lower body negative pressure training. 33rd International Symposium on the Autonomic Nervous System, 2022-11-02 - 2022-11-05, Hawaii.

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Kurzfassung

Background: Autonomic cardiovascular regulation is impaired both after bedrest and after space flight. Impaired autonomic control likely limits cardiovascular adaptation to physiological stresses such as standing. We hypothesized that 6 h daily lower body negative pressure (LBNP) helps maintain heart rate (HR), heart rate variability (HRV) and baroreflex sensitivity (BRS) following strict head-down tilt bedrest, an established terrestrial space-analogue. Methods: We included 23 healthy persons (12 women, 34.5 ± 9 years, 23.9 ± 2.8 kg/m²) in the 30 days SANS_CM strict head down tilt bedrest study. Subjects were randomly assigned to 6 h daily LBNP training with moderate intensity (LBNP, - 25 mmHg) or 6 h daily sitting (seated, positive control). We measured HR and finger blood pressure before bedrest and at the end of bedrest during head-up tilt testing. We assessed HRV in the time and frequency domains, systolic blood pressure variability in the low frequency range (LF-SBP), and baroreflex sensitivity using cross spectral analysis (BRS-LF). We analyzed stationary time series during the last 5 min supine and during minutes 2–6 at 80 degrees head-up tilt. Results: Supine HR increased during bedrest (LBNP group: 67 ± 9 vs. 74 ± 11; seated: 66 ± 10 vs. 71 ± 12 bpm; p \0.001) and the orthostatic HR response was enhanced (HR upright: 90 ± 10 vs. 112 ± 13 bpm; 86 ± 12 vs. 109 ± 13 bpm; p\ 0.0001). HRV in the time domain was reduced after bedrest while supine (rmssd: 37 ± 24 vs. 27 ± 14 ms; 50 ± 44 vs. 30 ± 20 ms; p\ 0.017) and upright (15 ± 5 vs. 8 ± 4 ms and 28 ± 21 vs. 14 ± 10 ms; p \0.001). HRV in the frequency domain (total power, LF- and HF power) tended to decrease while supine and standing but the bedrest effect did not reach significance. Supine and upright LF/HF ratios did not differ after bedrest. The tilt induced increase of LF-SBP tended to be enhanced after bedrest (p = 0.0547). Baroreflex mediated vagal HR control was reduced after bedrest at rest (p = 0.011) and during tilt (p \0.0001). No interactions between groups and conditions were detected. Conclusions: Six hours of daily moderate intensity LBNP training or seating do not completely preserve autonomic cardiovascular autonomic control during 30 days strict head-down tilt bedrest. Additional countermeasures, such as physical exercise, may be required.

elib-URL des Eintrags:https://elib.dlr.de/190348/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Autonomic cardiovascular control following 30 days strict head down tilt bedrest with six hours of daily lower body negative pressure training
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Möstl, S.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Hönemann, J.Univ of Cologne and German Aerospace Cntr, Institute of Aerospace Medicine, Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Souza, H.C.D.Laboratory of Exercise Physiology and Cardiovascular Physiotherapy, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, SP, 14049-900, BrazilNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706NICHT SPEZIFIZIERT
Tank, J.Cardiovascular Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Tank (at) dlr.dehttps://orcid.org/0000-0002-5672-1187NICHT SPEZIFIZIERT
Datum:2022
Referierte Publikation:Ja
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:cardiovascular; head down tilt; LBNP; lower body negative pressure training
Veranstaltungstitel:33rd International Symposium on the Autonomic Nervous System
Veranstaltungsort:Hawaii
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:2 November 2022
Veranstaltungsende:5 November 2022
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - CardioBrain
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin
Institut für Luft- und Raumfahrtmedizin > Kardiovaskuläre Luft- und Raumfahrtmedizin
Institut für Luft- und Raumfahrtmedizin > Leitungsbereich ME
Hinterlegt von: Schrage, Larissa
Hinterlegt am:22 Nov 2022 12:48
Letzte Änderung:24 Apr 2024 20:51

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